David Sinclair | Genetics

David Andrew Sinclair, Ph.D.

Professor of Genetics

Phone:

617/432-3931

Fax:

617/432-6225

david_sinclair@hms.harvard.edu

Tabs

Publications

NAD(+) Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair.

David Andrew Sinclair, Ph.D.

Cell metabolism, October 11, 2016

Fang EF, Kassahun H, Croteau DL, Scheibye-Knudsen M, Marosi K, Lu H, Shamanna RA, Kalyanasundaram S, Bollineni RC, Wilson MA, Iser WB, Wollman BN, Morevati M, Li J, Kerr JS, Lu Q, Waltz TB, Tian J, Sinclair DA, Mattson MP, Nilsen H, Bohr VA

Link to abstract on PubMed

JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.

David Andrew Sinclair, Ph.D.

Cell reports, August 25, 2016

Van Meter M, Simon M, Tombline G, May A, Morello TD, Hubbard BP, Bredbenner K, Park R, Sinclair DA, Bohr VA, Gorbunova V, Seluanov A

Link to abstract on PubMed

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds.

David Andrew Sinclair, Ph.D.

Nature reviews. Molecular cell biology, August 24, 2016

Bonkowski MS, Sinclair DA

Link to abstract on PubMed

Restoring stem cells - all you need is NAD(.).

David Andrew Sinclair, Ph.D.

Cell research, June 24, 2016

Wu LE, Sinclair DA

Link to abstract on PubMed

Why NAD(+) Declines during Aging: It's Destroyed.

David Andrew Sinclair, Ph.D.

Cell metabolism, June 14, 2016

Schultz MB, Sinclair DA

Link to abstract on PubMed

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

David Andrew Sinclair, Ph.D.

Cell metabolism, June 14, 2016

Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F...

Link to abstract on PubMed

Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance.

David Andrew Sinclair, Ph.D.

Aging cell, April 20, 2016

Mohamad M, Mitchell SJ, Wu LE, White MY, Cordwell SJ, Mach J, Solon-Biet SM, Boyer D, Nines D, Das A, Catherine Li SY, Warren A, Hilmer SN, Fraser R, Sinclair DA, Simpson SJ, de Cabo R, Le Couteur DG, Cogger VC

Link to abstract on PubMed

Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency.

David Andrew Sinclair, Ph.D.

Scientific reports, March 18, 2016

Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, St John JC

Link to abstract on PubMed

C. elegans lifespan extension by osmotic stress requires FUdR, base excision repair, FOXO, and sirtuins.

David Andrew Sinclair, Ph.D.

Mechanisms of ageing and development, February 22, 2016

Anderson EN, Corkins ME, Li JC, Singh K, Parsons S, Tucey TM, Sorkaç A, Huang H, Dimitriadi M, Sinclair DA, Hart AC

Link to abstract on PubMed

Synthesis and Assay of SIRT1-Activating Compounds.

David Andrew Sinclair, Ph.D.

Methods in enzymology, February 9, 2016

Dai H, Ellis JL, Sinclair DA, Hubbard BP

Link to abstract on PubMed

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