Frederick Alt | Genetics

Frederick Alt

Frederick W. Alt, PH.D.

Charles A. Janeway Professor of Pediatrics

HMS BBS Faculty

HHMI Investigator

Phone:

617/919-2539

Fax:

617/730-0948

alt@enders.tch.harvard.edu

Tabs

Research

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Publications

Structure of the gamma/delta T cell receptor of a human thymocyte clone.

Frederick W. Alt, PH.D.

The Journal of experimental medicine, October 1, 1988

Okada A, Bank I, Rogozinski L, Takihara Y, Mak TW, Chess L, Alt FW

Link to abstract on PubMed

N-myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization.

Frederick W. Alt, PH.D.

The Journal of cell biology, October 1, 1988

Mugrauer G, Alt FW, Ekblom P

Link to abstract on PubMed

Reconstruction of an immune system.

Frederick W. Alt, PH.D.

Science (New York, N.Y.), September 23, 1988

Yancopoulos GD, Alt FW

Link to abstract on PubMed

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism.

Keith Blackwell, Ph.D., M.D., Frederick W. Alt, PH.D.

Cell, August 12, 1988

Malynn BA, Blackwell TK, Fulop GM, Rathbun GA, Furley AJ, Ferrier P, Heinke LB, Phillips RA, Yancopoulos GD, Alt FW

Link to abstract on PubMed

Developmentally regulated and strain-specific expression of murine VH gene families.

Frederick W. Alt, PH.D.

The Journal of experimental medicine, July 1, 1988

Yancopoulos GD, Malynn BA, Alt FW

Link to abstract on PubMed

N-myc oncogene expression in histopathologically unrelated bilateral pediatric renal tumors.

Frederick W. Alt, PH.D.

Cancer, May 1, 1988

Nisen PD, Rich MA, Gloster E, Valderrama E, Saric O, Shende A, Lanzkowsky P, Alt FW

Link to abstract on PubMed

Mitogen- and IL-4-regulated expression of germ-line Ig gamma 2b transcripts: evidence for directed heavy chain class switching.

Frederick W. Alt, PH.D.

Cell, April 22, 1988

Lutzker S, Rothman P, Pollock R, Coffman R, Alt FW

Link to abstract on PubMed

Structure and expression of germ line immunoglobulin gamma 2b transcripts.

Frederick W. Alt, PH.D.

Molecular and cellular biology, April 1, 1988

Lutzker S, Alt FW

Link to abstract on PubMed

Sequence and organization of the human T cell delta chain gene.

Frederick W. Alt, PH.D.

European journal of immunology, February 1, 1988

Takihara Y, Champagne E, Griesser H, Kimura N, Tkachuk D, Reimann J, Okada A, Alt FW, Chess L, Minden M

Link to abstract on PubMed

Differential expression of myc-family genes during development: normal and deregulated N-myc expression in transgenic mice.

Frederick W. Alt, PH.D.

Current topics in microbiology and immunology, January 1, 1988

Dildrop R, Zimmerman K, DePinho RA, Yancopoulos GD, Tesfaye A, Alt FW

Link to abstract on PubMed

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