Frederick Alt | Genetics

Frederick W. Alt, PH.D.

Charles A. Janeway Professor of Pediatrics

HMS BBS Faculty

HHMI Investigator

Phone:

617/919-2539

Fax:

617/730-0948

alt@enders.tch.harvard.edu

Tabs

Research

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Publications

Early human IgH gene assembly in Epstein-Barr virus-transformed fetal B cell lines. Preferential utilization of the most JH-proximal D segment (DQ52) and two unusual VH-related rearrangements.

Frederick W. Alt, PH.D.

The Journal of experimental medicine, April 1, 1989

Nickerson KG, Berman J, Glickman E, Chess L, Alt FW

Link to abstract on PubMed

IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.

Frederick W. Alt, PH.D.

The EMBO journal, April 1, 1989

Dildrop R, Ma A, Zimmerman K, Hsu E, Tesfaye A, DePinho R, Alt FW

Link to abstract on PubMed

Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.

Keith Blackwell, Ph.D., M.D., Frederick W. Alt, PH.D.

The EMBO journal, March 1, 1989

Blackwell TK, Malynn BA, Pollock RR, Ferrier P, Covey LR, Fulop GM, Phillips RA, Yancopoulos GD, Alt FW

Link to abstract on PubMed

Mechanism and developmental program of immunoglobulin gene rearrangement in mammals.

Keith Blackwell, Ph.D., M.D., Frederick W. Alt, PH.D.

Annual review of genetics, January 1, 1989

Blackwell TK, Alt FW

Link to abstract on PubMed

Chromosomal location of N-myc and L-myc genes in the mouse.

Frederick W. Alt, PH.D.

Oncogene research, January 1, 1989

Campbell GR, Zimmerman K, Blank RD, Alt FW, D'Eustachio P

Link to abstract on PubMed

T cell receptor DJ but not VDJ rearrangement within a recombination substrate introduced into a pre-B cell line.

Frederick W. Alt, PH.D.

International immunology, January 1, 1989

Ferrier P, Covey LR, Suh H, Winoto A, Hood L, Alt FW

Link to abstract on PubMed

Immunoglobulin VH gene expression in human B cell lines and tumors: biased VH gene expression in chronic lymphocytic leukemia.

Frederick W. Alt, PH.D.

International immunology, January 1, 1989

Logtenberg T, Schutte ME, Inghirami G, Berman JE, Gmelig-Meyling FH, Insel RA, Knowles DM, Alt FW

Link to abstract on PubMed

Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells.

Frederick W. Alt, PH.D.

The Journal of experimental medicine, December 1, 1988

Rothman P, Lutzker S, Cook W, Coffman R, Alt FW

Link to abstract on PubMed

Gene expression in renal growth and regrowth.

Frederick W. Alt, PH.D.

The Journal of urology, November 1, 1988

Sawczuk IS, Olsson CA, Buttyan R, Nguyen-Huu MC, Zimmerman KA, Alt FW, Zakeri Z, Wolgemuth D, Reitelman C

Link to abstract on PubMed

Structure of the gamma/delta T cell receptor of a human thymocyte clone.

Frederick W. Alt, PH.D.

The Journal of experimental medicine, October 1, 1988

Okada A, Bank I, Rogozinski L, Takihara Y, Mak TW, Chess L, Alt FW

Link to abstract on PubMed

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