Our lab studies the development and function somatosensory circuits that mediate our sense of touch and sensations from the gastrointestinal system. We are also interested in the dysfunction of these circuits, and how this applies to disorders such as autism spectrum disorders, so that we may identify novel therapeutic approaches.
Address:
Department of Genetics, Harvard Medical School
185 Cambridge Street, Room 6.808
Boston, MA 02116
Emerging Therapeutic Strategies for Fragile X Syndrome: Q&A.
Authors: Authors: Alusi G, Berry-Kravis E, Nelson D, Orefice LL, Booker SA.
ACS Chem Neurosci
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ACS Chem Neurosci
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DeepEthogram, a machine learning pipeline for supervised behavior classification from raw pixels.
Authors: Authors: Bohnslav JP, Wimalasena NK, Clausing KJ, Dai YY, Yarmolinsky DA, Cruz T, Kashlan AD, Chiappe ME, Orefice LL, Woolf CJ, Harvey CD.
Elife
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Elife
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Peripheral Somatosensory Neuron Dysfunction: Emerging Roles in Autism Spectrum Disorders.
Meissner corpuscles and their spatially intermingled afferents underlie gentle touch perception.
Authors: Authors: Neubarth NL, Emanuel AJ, Liu Y, Springel MW, Handler A, Zhang Q, Lehnert BP, Guo C, Orefice LL, Abdelaziz A, DeLisle MM, Iskols M, Rhyins J, Kim SJ, Cattel SJ, Regehr W, Harvey CD, Drugowitsch J, Ginty DD.
Science
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Science
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Outside-in: Rethinking the etiology of autism spectrum disorders
Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models.
Authors: Authors: Orefice LL, Mosko JR, Morency DT, Wells MF, Tasnim A, Mozeika SM, Ye M, Chirila AM, Emanuel AJ, Rankin G, Fame RM, Lehtinen MK, Feng G, Ginty DD.
Cell
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Cell
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Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis.
Authors: Authors: Ast T, Meisel JD, Patra S, Wang H, Grange RMH, Kim SH, Calvo SE, Orefice LL, Nagashima F, Ichinose F, Zapol WM, Ruvkun G, Barondeau DP, Mootha VK.
Cell
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Cell
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Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice.
Authors: Authors: Chen CM, Orefice LL, Chiu SL, LeGates TA, Hattar S, Huganir RL, Zhao H, Xu B, Kuruvilla R.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn.
Authors: Authors: Abraira VE, Kuehn ED, Chirila AM, Springel MW, Toliver AA, Zimmerman AL, Orefice LL, Boyle KA, Bai L, Song BJ, Bashista KA, O'Neill TG, Zhuo J, Tsan C, Hoynoski J, Rutlin M, Kus L, Niederkofler V, Watanabe M, Dymecki SM, Nelson SB, Heintz N, Hughes DI, Ginty DD.
Cell
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Cell
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Peripheral Mechanosensory Neuron Dysfunction Underlies Tactile and Behavioral Deficits in Mouse Models of ASDs.
Authors: Authors: Orefice LL, Zimmerman AL, Chirila AM, Sleboda SJ, Head JP, Ginty DD.
Cell
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Cell
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