Alexander Gimelbrant headshot
Alexander Gimelbrant, Ph.D.
Associate Professor of Genetics
KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance.
Authors: Authors: Hinohara K, Wu HJ, Vigneau S, McDonald TO, Igarashi KJ, Yamamoto KN, Madsen T, Fassl A, Egri SB, Papanastasiou M, Ding L, Peluffo G, Cohen O, Kales SC, Lal-Nag M, Rai G, Maloney DJ, Jadhav A, Simeonov A, Wagle N, Brown M, Meissner A, Sicinski P, Jaffe JD, Jeselsohn R, Gimelbrant AA, Michor F, Polyak K.
Cancer Cell
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Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.
Authors: Authors: Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M.
Cell
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High prevalence of clonal monoallelic expression.
Authors: Authors: Vigneau S, Vinogradova S, Savova V, Gimelbrant A.
Nat Genet
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Widespread monoallelic expression on human autosomes.
Authors: Authors: Gimelbrant A, Hutchinson JN, Thompson BR, Chess A.
Science
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Risk alleles of genes with monoallelic expression are enriched in gain-of-function variants and depleted in loss-of-function variants for neurodevelopmental disorders.
Authors: Authors: Savova V, Vinogradova S, Pruss D, Gimelbrant AA, Weiss LA.
Mol Psychiatry
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An epigenetic state associated with areas of gene duplication.
Authors: Authors: Gimelbrant AA, Chess A.
Genome Res
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Tumor-suppressor genes that escape from X-inactivation contribute to cancer sex bias.
Authors: Authors: Dunford A, Weinstock DM, Savova V, Schumacher SE, Cleary JP, Yoda A, Sullivan TJ, Hess JM, Gimelbrant AA, Beroukhim R, Lawrence MS, Getz G, Lane AA.
Nat Genet
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Monoallelic expression and asynchronous replication of p120 catenin in mouse and human cells.
Authors: Authors: Gimelbrant AA, Ensminger AW, Qi P, Zucker J, Chess A.
J Biol Chem
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Genes with monoallelic expression contribute disproportionately to genetic diversity in humans.
Authors: Authors: Savova V, Chun S, Sohail M, McCole RB, Witwicki R, Gai L, Lenz TL, Wu CT, Sunyaev SR, Gimelbrant AA.
Nat Genet
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Selective pressures on the olfactory receptor repertoire since the human-chimpanzee divergence.
Authors: Authors: Gimelbrant AA, Skaletsky H, Chess A.
Proc Natl Acad Sci U S A
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