Carla Kim headshot
Carla Kim, Ph.D.
Professor of Genetics

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information:

Developmental biology. Mesenchymal progenitor panoply.
Authors: Authors: Lee JH, Kim CF.
View full abstract on Pubmed
Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia.
Authors: Authors: Tropea KA, Leder E, Aslam M, Lau AN, Raiser DM, Lee JH, Balasubramaniam V, Fredenburgh LE, Alex Mitsialis S, Kourembanas S, Kim CF.
Am J Physiol Lung Cell Mol Physiol
View full abstract on Pubmed
Bone marrow-derived multipotent stromal cells attenuate inflammation in obliterative airway disease in mouse tracheal allografts.
Authors: Authors: Casey A, Dirks F, Liang OD, Harrach H, Schuette-Nuetgen K, Leeman K, Kim CF, Gerard C, Subramaniam M.
Stem Cells Int
View full abstract on Pubmed
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.
Authors: Authors: Yu M, Mazor T, Huang H, Huang HT, Kathrein KL, Woo AJ, Chouinard CR, Labadorf A, Akie TE, Moran TB, Xie H, Zacharek S, Taniuchi I, Roeder RG, Kim CF, Zon LI, Fraenkel E, Cantor AB.
Mol Cell
View full abstract on Pubmed
Non-small-cell lung cancers: a heterogeneous set of diseases.
Authors: Authors: Chen Z, Fillmore CM, Hammerman PS, Kim CF, Wong KK.
Nat Rev Cancer
View full abstract on Pubmed
Isolation and characterization of distal lung progenitor cells.
Authors: Authors: Driscoll B, Kikuchi A, Lau AN, Lee J, Reddy R, Jesudason E, Kim CF, Warburton D.
Methods Mol Biol
View full abstract on Pubmed
Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis.
Authors: Authors: Lau AN, Curtis SJ, Fillmore CM, Rowbotham SP, Mohseni M, Wagner DE, Beede AM, Montoro DT, Sinkevicius KW, Walton ZE, Barrios J, Weiss DJ, Camargo FD, Wong KK, Kim CF.
View full abstract on Pubmed
Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci.
Authors: Authors: Zacharek SJ, Fillmore CM, Lau AN, Gludish DW, Chou A, Ho JW, Zamponi R, Gazit R, Bock C, J├Ąger N, Smith ZD, Kim TM, Saunders AH, Wong J, Lee JH, Roach RR, Rossi DJ, Meissner A, Gimelbrant AA, Park PJ, Kim CF.
Cell Stem Cell
View full abstract on Pubmed
An airway organoid is forever.
Authors: Authors: Paschini M, Kim CF.
View full abstract on Pubmed
Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.
Authors: Authors: Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF.
Proc Natl Acad Sci U S A
View full abstract on Pubmed