Carla Kim headshot
Carla Kim, Ph.D.
Professor of Genetics

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information:
http://kim.tchlab.org/

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.
Authors: Authors: Zhang H, Qi J, Reyes JM, Li L, Rao PK, Li F, Lin CY, Perry JA, Lawlor MA, Federation A, De Raedt T, Li YY, Liu Y, Duarte MA, Zhang Y, Herter-Sprie GS, Kikuchi E, Carretero J, Perou CM, Reibel JB, Paulk J, Bronson RT, Watanabe H, Brainson CF, Kim CF, Hammerman PS, Brown M, Cichowski K, Long H, Bradner JE, Wong KK.
Cancer Discov
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Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury.
Authors: Authors: Chen H, Matsumoto K, Brockway BL, Rackley CR, Liang J, Lee JH, Jiang D, Noble PW, Randell SH, Kim CF, Stripp BR.
Stem Cells
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The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
Authors: Authors: Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH.
Genes Dev
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Tracing the potential of lung progenitors.
Authors: Authors: Mahoney JE, Kim CF.
Nat Biotechnol
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The bed and the bugs: interactions between the tumor microenvironment and cancer stem cells.
Authors: Authors: CastaƱo Z, Fillmore CM, Kim CF, McAllister SS.
Semin Cancer Biol
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Use of gene expression profiling to direct in vivo molecular imaging of lung cancer.
Authors: Authors: Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R.
Proc Natl Acad Sci U S A
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EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors.
Authors: Authors: Fillmore CM, Xu C, Desai PT, Berry JM, Rowbotham SP, Lin YJ, Zhang H, Marquez VE, Hammerman PS, Wong KK, Kim CF.
Nature
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Stem cells and regenerative medicine in lung biology and diseases.
Authors: Authors: Lau AN, Goodwin M, Kim CF, Weiss DJ.
Mol Ther
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Identification of bronchioalveolar stem cells in normal lung and lung cancer.
Authors: Authors: Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT, Jacks T.
Cell
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Developmental biology. Mesenchymal progenitor panoply.
Authors: Authors: Lee JH, Kim CF.
Science
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