David Sinclair headshot
David Andrew Sinclair, Ph.D.
Professor of Genetics
Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice.
Authors: Authors: Wahl D, Solon-Biet SM, Wang QP, Wali JA, Pulpitel T, Clark X, Raubenheimer D, Senior AM, Sinclair DA, Cooney GJ, de Cabo R, Cogger VC, Simpson SJ, Le Couteur DG.
Cell Rep
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Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.
Authors: Authors: Uddin GM, Youngson NA, Doyle BM, Sinclair DA, Morris MJ.
Sci Rep
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Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency.
Authors: Authors: Cagnone GL, Tsai TS, Makanji Y, Matthews P, Gould J, Bonkowski MS, Elgass KD, Wong AS, Wu LE, McKenzie M, Sinclair DA, St John JC.
Sci Rep
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SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass.
Authors: Authors: Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, González-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R.
Aging Cell
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Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.
Authors: Authors: Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M.
Nat Chem Biol
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The longevity of sirtuins.
Authors: Authors: Sinclair D, Verdin E.
Cell Rep
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Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase.
Authors: Authors: Vendrell A, Martínez-Pastor M, González-Novo A, Pascual-Ahuir A, Sinclair DA, Proft M, Posas F.
EMBO Rep
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Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy.
Authors: Authors: Armour SM, Baur JA, Hsieh SN, Land-Bracha A, Thomas SM, Sinclair DA.
Aging (Albany NY)
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The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.
Authors: Authors: Barbosa MT, Soares SM, Novak CM, Sinclair D, Levine JA, Aksoy P, Chini EN.
FASEB J
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HST2 mediates SIR2-independent life-span extension by calorie restriction.
Authors: Authors: Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, Wang C, Lin SJ, Sinclair DA.
Science
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