David Sinclair headshot
David Andrew Sinclair, Ph.D.
Professor of Genetics
Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14.
Authors: Authors: Vatner DE, Zhang J, Oydanich M, Guers J, Katsyuba E, Yan L, Sinclair D, Auwerx J, Vatner SF.
Aging Cell
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Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease.
Authors: Authors: Cronise RJ, Sinclair DA, Bremer AA.
Metab Syndr Relat Disord
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Oogonial stem cells as a model to study age-associated infertility in women.
Authors: Authors: Garg N, Sinclair DA.
Reprod Fertil Dev
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The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression.
Authors: Authors: Miranda MX, van Tits LJ, Lohmann C, Arsiwala T, Winnik S, Tailleux A, Stein S, Gomes AP, Suri V, Ellis JL, Lutz TA, Hottiger MO, Sinclair DA, Auwerx J, Schoonjans K, Staels B, L├╝scher TF, Matter CM.
Eur Heart J
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World Health Organization guideline development: an evaluation.
Authors: Authors: Sinclair D, Isba R, Kredo T, Zani B, Smith H, Garner P.
PLoS One
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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
Authors: Authors: Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA.
Cell Metab
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Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy.
Authors: Authors: Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA.
Aging (Albany NY)
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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span.
Authors: Authors: Pearson KJ, Baur JA, Lewis KN, Peshkin L, Price NL, Labinskyy N, Swindell WR, Kamara D, Minor RK, Perez E, Jamieson HA, Zhang Y, Dunn SR, Sharma K, Pleshko N, Woollett LA, Csiszar A, Ikeno Y, Le Couteur D, Elliott PJ, Becker KG, Navas P, Ingram DK, Wolf NS, Ungvari Z, Sinclair DA, de Cabo R.
Cell Metab
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Design and synthesis of compounds that extend yeast replicative lifespan.
Authors: Authors: Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE, Sinclair DA.
Aging Cell
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Measurement of the total active 8B solar neutrino flux at the Sudbury Neutrino Observatory with enhanced neutral current sensitivity.
Authors: Authors: Ahmed SN, Anthony AE, Beier EW, Bellerive A, Biller SD, Boger J, Boulay MG, Bowler MG, Bowles TJ, Brice SJ, Bullard TV, Chan YD, Chen M, Chen X, Cleveland BT, Cox GA, Dai X, Dalnoki-Veress F, Doe PJ, Dosanjh RS, Doucas G, Dragowsky MR, Duba CA, Duncan FA, Dunford M, Dunmore JA, Earle ED, Elliott SR, Evans HC, Ewan GT, Farine J, Fergani H, Fleurot F, Formaggio JA, Fowler MM, Frame K, Fulsom BG, Gagnon N, Graham K, Grant DR, Hahn RL, Hall JC, Hallin AL, Hallman ED, Hamer AS, Handler WB, Hargrove CK, Harvey PJ, Hazama R, Heeger KM, Heintzelman WJ, Heise J, Helmer RL, Hemingway RJ, Hime A, Howe MA, Jagam P, Jelley NA, Klein JR, Kos MS, Krumins AV, Kutter T, Kyba CC, Labranche H, Lange R, Law J, Lawson IT, Lesko KT, Leslie JR, Levine I, Luoma S, MacLellan R, Majerus S, Mak HB, Maneira J, Marino AD, McCauley N, McDonald AB, McGee S, McGregor G, Mifflin C, Miknaitis KK, Miller GG, Moffat BA, Nally CW, Nickel BG, Noble AJ, Norman EB, Oblath NS, Okada CE, Ollerhead RW, Orrell JL, Oser SM, Ouellet C, Peeters SJ, Poon AW, Robertson BC, Robertson RG, Rollin E, Rosendahl SS, Rusu VL, Schwendener MH, Simard O, Simpson JJ, Sims CJ, Sinclair D, Skensved P, Smith MW, Starinsky N, Stokstad RG, Stonehill LC, Tafirout R, Takeuchi Y, Tesic G, Thomson M, Thorman M, Van Berg R, Van de Water RG, Virtue CJ, Wall BL, Waller D, Waltham CE, Tseung HW, Wark DL, West N, Wilhelmy JB, Wilkerson JF, Wilson JR, Wouters JM, Yeh M, Zuber K.
Phys Rev Lett
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