David Livingston headshot
David Morse Livingston, M.D
Emil Frei Distinguished Professor of Medicine
BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.
Authors: Authors: Vohhodina J, Goehring LJ, Liu B, Kong Q, Botchkarev VV, Huynh M, Liu Z, Abderazzaq FO, Clark AP, Ficarro SB, Marto JA, Hatchi E, Livingston DM.
Nat Commun
View full abstract on Pubmed
BRCA1 and RNAi factors promote repair mediated by small RNAs and PALB2-RAD52.
Authors: Authors: Hatchi E, Goehring L, Landini S, Skourti-Stathaki K, DeConti DK, Abderazzaq FO, Banerjee P, Demers TM, Wang YE, Quackenbush J, Livingston DM.
Nature
View full abstract on Pubmed
Opening a Door to PARP Inhibitor-Induced Lethality in HR-Proficient Human Tumor Cells.
Authors: Authors: Hatchi E, Livingston DM.
Cancer Cell
View full abstract on Pubmed
RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci.
Authors: Authors: Vohhodina J, Toomire KJ, Petit SA, Micevic G, Kumari G, Botchkarev VV, Li Z, Livingston DM, Hu Y.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Inadequate DNA Damage Repair Promotes Mammary Transdifferentiation, Leading to BRCA1 Breast Cancer.
Authors: Authors: Wang H, Xiang D, Liu B, He A, Randle HJ, Zhang KX, Dongre A, Sachs N, Clark AP, Tao L, Chen Q, Botchkarev VV, Xie Y, Dai N, Clevers H, Li Z, Livingston DM.
Cell
View full abstract on Pubmed
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1a activation.
Authors: Authors: Li AG, Murphy EC, Culhane AC, Powell E, Wang H, Bronson RT, Von T, Giobbie-Hurder A, Gelman RS, Briggs KJ, Piwnica-Worms H, Zhao JJ, Kung AL, Kaelin WG, Livingston DM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Trauma-Induced Acute X Chromosome Skewing in White Blood Cells Represents an Immuno-Modulatory Mechanism Unique to Females and a Likely Contributor to Sex-Based Outcome Differences.
Authors: Authors: Pena G, Michalski C, Donnelly RJ, Qin Y, Sifri ZC, Mosenthal AC, Livingston DH, Spolarics Z.
Shock
View full abstract on Pubmed
Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.
Authors: Authors: Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.
Clin Cancer Res
View full abstract on Pubmed
Two familial ALS proteins function in prevention/repair of transcription-associated DNA damage.
Authors: Authors: Hill SJ, Mordes DA, Cameron LA, Neuberg DS, Landini S, Eggan K, Livingston DM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.
Authors: Authors: Wang H, Bierie B, Li AG, Pathania S, Toomire K, Dimitrov SD, Liu B, Gelman R, Giobbie-Hurder A, Feunteun J, Polyak K, Livingston DM.
Mol Cell
View full abstract on Pubmed