Frederick Ausubel headshot
Frederick M. Ausubel
Professor of Genetics, Emeritus

The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.

The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events.
Authors: Authors: Urbach JM, Ausubel FM.
Proc Natl Acad Sci U S A
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Plant immunity triggered by engineered in vivo release of oligogalacturonides, damage-associated molecular patterns.
Authors: Authors: Benedetti M, Pontiggia D, Raggi S, Cheng Z, Scaloni F, Ferrari S, Ausubel FM, Cervone F, De Lorenzo G.
Proc Natl Acad Sci U S A
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Pseudomonas aeruginosa disrupts Caenorhabditis elegans iron homeostasis, causing a hypoxic response and death.
Authors: Authors: Kirienko NV, Kirienko DR, Larkins-Ford J, Wählby C, Ruvkun G, Ausubel FM.
Cell Host Microbe
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Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses.
Authors: Authors: Pukkila-Worley R, Ausubel FM, Mylonakis E.
PLoS Pathog
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The G protein-coupled receptor FSHR-1 is required for the Caenorhabditis elegans innate immune response.
Authors: Authors: Powell JR, Kim DH, Ausubel FM.
Proc Natl Acad Sci U S A
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Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses.
Authors: Authors: Begun J, Gaiani JM, Rohde H, Mack D, Calderwood SB, Ausubel FM, Sifri CD.
PLoS Pathog
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The worm has turned--microbial virulence modeled in Caenorhabditis elegans.
Authors: Authors: Sifri CD, Begun J, Ausubel FM.
Trends Microbiol
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Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens.
Authors: Authors: Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM.
Science
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Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms.
Authors: Authors: Kudva IT, Evans PS, Perna NT, Barrett TJ, Ausubel FM, Blattner FR, Calderwood SB.
J Bacteriol
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Three unique mutants of Arabidopsis identify eds loci required for limiting growth of a biotrophic fungal pathogen.
Authors: Authors: Dewdney J, Reuber TL, Wildermuth MC, Devoto A, Cui J, Stutius LM, Drummond EP, Ausubel FM.
Plant J
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