Frederick Ausubel headshot
Frederick M. Ausubel
Professor of Genetics, Emeritus

The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.

Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways.
Authors: Authors: Yuen GJ, Ausubel FM.
Virulence
View full abstract on Pubmed
Tracing My Roots: How I Became a Plant Biologist.
Authors: Authors: Ausubel FM.
Annu Rev Genet
View full abstract on Pubmed
Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters.
Authors: Authors: Kim W, Steele AD, Zhu W, Csatary EE, Fricke N, Dekarske MM, Jayamani E, Pan W, Kwon B, Sinitsa IF, Rosen JL, Conery AL, Fuchs BB, Vlahovska PM, Ausubel FM, Gao H, Wuest WM, Mylonakis E.
ACS Infect Dis
View full abstract on Pubmed
Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants.
Authors: Authors: Drenkard E, Hibbler RM, Gutu DA, Eaton AD, Silverio AL, Ausubel FM, Hurley BP, Yonker LM.
J Vis Exp
View full abstract on Pubmed
Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization.
Authors: Authors: Haller S, Franchet A, Hakkim A, Chen J, Drenkard E, Yu S, Schirmeier S, Li Z, Martins N, Ausubel FM, LiƩgeois S, Ferrandon D.
EMBO Rep
View full abstract on Pubmed
A new class of synthetic retinoid antibiotics effective against bacterial persisters.
Authors: Authors: Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E.
Nature
View full abstract on Pubmed
Rhizosphere-associated Pseudomonas induce systemic resistance to herbivores at the cost of susceptibility to bacterial pathogens.
Authors: Authors: Haney CH, Wiesmann CL, Shapiro LR, Melnyk RA, O'Sullivan LR, Khorasani S, Xiao L, Han J, Bush J, Carrillo J, Pierce NE, Ausubel FM.
Mol Ecol
View full abstract on Pubmed
Overview of Next-Generation Sequencing Technologies.
Authors: Authors: Slatko BE, Gardner AF, Ausubel FM.
Curr Protoc Mol Biol
View full abstract on Pubmed
An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections.
Authors: Authors: Koeva M, Gutu AD, Hebert W, Wager JD, Yonker LM, O'Toole GA, Ausubel FM, Moskowitz SM, Joseph-McCarthy D.
Antimicrob Agents Chemother
View full abstract on Pubmed
Investment in secreted enzymes during nutrient-limited growth is utility dependent.
Authors: Authors: Cezairliyan B, Ausubel FM.
Proc Natl Acad Sci U S A
View full abstract on Pubmed