Frederick W. Alt
Frederick W. Alt, PhD
Charles A. Janeway Professor of Pediatrics

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected].
Authors: Authors: Muindi K, Cernadas M, Watts GF, Royle L, Neville DC, Dwek RA, Besra GS, Rudd PM, Butters TD, Brenner MB.
Proc Natl Acad Sci U S A
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Microsomal triglyceride transfer protein regulates endogenous and exogenous antigen presentation by group 1 CD1 molecules.
Authors: Authors: Kaser A, Hava DL, Dougan SK, Chen Z, Zeissig S, Brenner MB, Blumberg RS.
Eur J Immunol
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Apolipoprotein-mediated pathways of lipid antigen presentation.
Authors: Authors: van den Elzen P, Garg S, León L, Brigl M, Leadbetter EA, Gumperz JE, Dascher CC, Cheng TY, Sacks FM, Illarionov PA, Besra GS, Kent SC, Moody DB, Brenner MB.
Nature
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Mechanism of CD1d-restricted natural killer T cell activation during microbial infection.
Authors: Authors: Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB.
Nat Immunol
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Conservation of CD1 intracellular trafficking patterns between mammalian species.
Authors: Authors: Dascher CC, Hiromatsu K, Xiong X, Sugita M, Buhlmann JE, Dodge IL, Lee SY, Roura-Mir C, Watts GF, Roy CJ, Behar SM, Clemens DL, Porcelli SA, Brenner MB.
J Immunol
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T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines.
Authors: Authors: Agace WW, Higgins JM, Sadasivan B, Brenner MB, Parker CM.
Curr Opin Cell Biol
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Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice.
Authors: Authors: Schön MP, Arya A, Murphy EA, Adams CM, Strauch UG, Agace WW, Marsal J, Donohue JP, Her H, Beier DR, Olson S, Lefrancois L, Brenner MB, Grusby MJ, Parker CM.
J Immunol
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Transendothelial chemotaxis of human alpha/beta and gamma/delta T lymphocytes to chemokines.
Authors: Authors: Roth SJ, Diacovo TG, Brenner MB, Rosat JP, Buccola J, Morita CT, Springer TA.
Eur J Immunol
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The beta 7 integrins in mucosal homing and retention.
Authors: Authors: Shaw SK, Brenner MB.
Semin Immunol
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Nonpeptide ligands for human gamma delta T cells.
Authors: Authors: Tanaka Y, Sano S, Nieves E, De Libero G, Rosa D, Modlin RL, Brenner MB, Bloom BR, Morita CT.
Proc Natl Acad Sci U S A
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