Frederick W. Alt
Frederick W. Alt, PhD
Charles A. Janeway Professor of Pediatrics

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

CD1a expression defines an interleukin-12 producing population of human dendritic cells.
Authors: Authors: Cernadas M, Lu J, Watts G, Brenner MB.
Clin Exp Immunol
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Role of adhesion molecules in synovial inflammation.
Authors: Authors: Agarwal SK, Brenner MB.
Curr Opin Rheumatol
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Mechanisms of Vdelta1 gammadelta T cell activation by microbial components.
Authors: Authors: Das H, Sugita M, Brenner MB.
J Immunol
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Understanding the function of CD1-restricted T cells.
Authors: Authors: Vincent MS, Gumperz JE, Brenner MB.
Nat Immunol
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Influence of Mycobacterium bovis bacillus Calmette Guérin on in vitro induction of CD1 molecules in human adherent mononuclear cells.
Authors: Authors: Giuliani A, Prete SP, Graziani G, Aquino A, Balduzzi A, Sugita M, Brenner MB, Iona E, Fattorini L, Orefici G, Porcelli SA, Bonmassar E.
Infect Immun
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IQGAP1 and calmodulin modulate E-cadherin function.
Authors: Authors: Li Z, Kim SH, Higgins JM, Brenner MB, Sacks DB.
J Biol Chem
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Clonally expanded Valpha12+ (AV12S1),CD8+ T cells from a patient with rheumatoid arthritis are autoreactive.
Authors: Authors: Behar SM, Roy C, Lederer J, Fraser P, Brenner MB.
Arthritis Rheum
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Expression of a candidate cadherin in T lymphocytes.
Authors: Authors: Cepek KL, Rimm DL, Brenner MB.
Proc Natl Acad Sci U S A
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Recognition of a lipid antigen by CD1-restricted alpha beta+ T cells.
Authors: Authors: Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB.
Nature
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Clonal V alpha 12.1+ T cell expansions in the peripheral blood of rheumatoid arthritis patients.
Authors: Authors: DerSimonian H, Sugita M, Glass DN, Maier AL, Weinblatt ME, Rème T, Brenner MB.
J Exp Med
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