Jack Szostak headshot
Jack William Szostak, Ph.D.
Professor of Genetics
Freeze-thaw cycles enable a prebiotically plausible and continuous pathway from nucleotide activation to nonenzymatic RNA copying.
Authors: Authors: Zhang SJ, Duzdevich D, Ding D, Szostak JW.
Proc Natl Acad Sci U S A
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Nonenzymatic assembly of active chimeric ribozymes from aminoacylated RNA oligonucleotides.
Authors: Authors: Radakovic A, DasGupta S, Wright TH, Aitken HRM, Szostak JW.
Proc Natl Acad Sci U S A
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Kinetic explanations for the sequence biases observed in the nonenzymatic copying of RNA templates.
Authors: Authors: Ding D, Zhou L, Giurgiu C, Szostak JW.
Nucleic Acids Res
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Structure-activity relationships in nonenzymatic template-directed RNA synthesis.
Authors: Authors: Giurgiu C, Fang Z, Aitken HRM, Kim SC, Pazienza L, Mittal S, Szostak JW.
Angew Chem Int Ed Engl
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Ribose Alters the Photochemical Properties of the Nucleobase in Thionated Nucleosides.
Authors: Authors: Janicki MJ, Kufner CL, Todd ZR, Kim SC, O'Flaherty DK, Szostak JW, Šponer J, Góra RW, Sasselov DD, Szabla R.
J Phys Chem Lett
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In search of the RNA world on Mars.
Authors: Authors: Mojarro A, Jin L, Szostak JW, Head JW, Zuber MT.
Geobiology
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Competition between bridged dinucleotides and activated mononucleotides determines the error frequency of nonenzymatic RNA primer extension.
Authors: Authors: Duzdevich D, Carr CE, Ding D, Zhang SJ, Walton TS, Szostak JW.
Nucleic Acids Res
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The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis.
Authors: Authors: Kim SC, O'Flaherty DK, Giurgiu C, Zhou L, Szostak JW.
J Am Chem Soc
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A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry.
Authors: Authors: Radakovic A, Wright TH, Lelyveld VS, Szostak JW.
Biochemistry
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Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization.
Authors: Authors: Zhang W, Kim SC, Tam CP, Lelyveld VS, Bala S, Chaput JC, Szostak JW.
Nucleic Acids Res
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