Jeannie T. Lee, M.D., Ph.D.
Phillip A. Sharp Chair in Molecular Biology, Massachusetts General Hospital
Vice Chair of the Department of Genetics, Harvard Medical School
Professor of Genetics and Pathology, Harvard Medical School
Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.
Authors: Authors: Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N.
Cancer Cell
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Cancer Cell
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Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome.
The pluripotency factor Oct4 interacts with Ctcf and also controls X-chromosome pairing and counting.
Authors: Authors: Donohoe ME, Silva SS, Pinter SF, Xu N, Lee JT.
Nature
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Nature
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Telomeric RNAs mark sex chromosomes in stem cells.
Authors: Authors: Zhang LF, Ogawa Y, Ahn JY, Namekawa SH, Silva SS, Lee JT.
Genetics
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Genetics
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XY and ZW: is meiotic sex chromosome inactivation the rule in evolution?
Characterization of two Mst1-deficient mouse models.
Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome.
Jeannie T. Lee.
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus.
Authors: Authors: Lindroth AM, Park YJ, McLean CM, Dokshin GA, Persson JM, Herman H, Pasini D, Miró X, Donohoe ME, Lee JT, Helin K, Soloway PD.
PLoS Genet
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PLoS Genet
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Higher order chromatin structure at the X-inactivation center via looping DNA.