Stephen Elledge headshot
Stephen J. Elledge
Gregor Mendel Professor of Genetics and of Medicine
Life-threatening influenza pneumonitis in a child with inherited IRF9 deficiency.
Authors: Authors: Hernandez N, Melki I, Jing H, Habib T, Huang SSY, Danielson J, Kula T, Drutman S, Belkaya S, Rattina V, Lorenzo-Diaz L, Boulai A, Rose Y, Kitabayashi N, Rodero MP, Dumaine C, Blanche S, Lebras MN, Leung MC, Mathew LS, Boisson B, Zhang SY, Boisson-Dupuis S, Giliani S, Chaussabel D, Notarangelo LD, Elledge SJ, Ciancanelli MJ, Abel L, Zhang Q, Marr N, Crow YJ, Su HC, Casanova JL.
J Exp Med
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Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.
Authors: Authors: Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ.
Genes Dev
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Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome.
Authors: Authors: Xu GJ, Kula T, Xu Q, Li MZ, Vernon SD, Ndung'u T, Ruxrungtham K, Sanchez J, Brander C, Chung RT, O'Connor KC, Walker B, Larman HB, Elledge SJ.
Science
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Brief report: VGLL4 is a novel regulator of survival in human embryonic stem cells.
Authors: Authors: Tajonar A, Maehr R, Hu G, Sneddon JB, Rivera-Feliciano J, Cohen DE, Elledge SJ, Melton DA.
Stem Cells
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Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress.
Authors: Authors: Ciccia A, Nimonkar AV, Hu Y, Hajdu I, Achar YJ, Izhar L, Petit SA, Adamson B, Yoon JC, Kowalczykowski SC, Livingston DM, Haracska L, Elledge SJ.
Mol Cell
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Functional identification of optimized RNAi triggers using a massively parallel sensor assay.
Authors: Authors: Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW.
Mol Cell
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The Fanconi anemia pathway promotes replication-dependent DNA interstrand cross-link repair.
Authors: Authors: Knipscheer P, Räschle M, Smogorzewska A, Enoiu M, Ho TV, Schärer OD, Elledge SJ, Walter JC.
Science
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Global protein stability profiling in mammalian cells.
Authors: Authors: Yen HC, Xu Q, Chou DM, Zhao Z, Elledge SJ.
Science
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The ubiquitin-specific protease USP28 is required for MYC stability.
Authors: Authors: Popov N, Wanzel M, Madiredjo M, Zhang D, Beijersbergen R, Bernards R, Moll R, Elledge SJ, Eilers M.
Nat Cell Biol
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The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression.
Authors: Authors: Turnell AS, Stewart GS, Grand RJ, Rookes SM, Martin A, Yamano H, Elledge SJ, Gallimore PH.
Nature
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