Susan Dymecki
Susan M. Dymecki, M.D.,Ph.D.
Professor of Genetics

The Dymecki lab studies how functional modularity arises within the brain serotonergic neuronal system and dynamically controls diverse processes ranging from respiration and thermal balance to emotional mood state to coping behaviors.

Understanding how this fundamental system develops at the molecular, cellular, and functional levels will help illuminate root causes of many brain disorders, paving the way for more targeted therapeutics and effective approaches to clinical conditions such as sudden infant death, major depression, and post-traumatic stress.

Using novel genetic tools for precision neural cell mapping in the mouse brain coupled with genomic, transcriptional, electrophysiological, and behavioral analyses, we examine the developmental specialization of subtypes of serotonin-producing neurons together with their network architecture, circuitry modulation, and selective roles in behavior. We probe how such neuronal diversity is generated and maintained, exploring the extent to which it is genetically programmed versus shaped by experience. Emerging is a neuronal structure-function map of substantial heterogeneity that suggests new ways to conceptualize and design treatments for serotonin-related disorders.

Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways.
Authors: Authors: Alekseyenko OV, Chan YB, Okaty BW, Chang Y, Dymecki SM, Kravitz EA.
Curr Biol
View full abstract on Pubmed
Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development.
Authors: Authors: Barrett KT, Dosumu-Johnson RT, Daubenspeck JA, Brust RD, Kreouzis V, Kim JC, Li A, Dymecki SM, Nattie EE.
J Neurosci
View full abstract on Pubmed
Projections and interconnections of genetically defined serotonin neurons in mice.
Authors: Authors: Bang SJ, Jensen P, Dymecki SM, Commons KG.
Eur J Neurosci
View full abstract on Pubmed
Ligand-activated Flpe for temporally regulated gene modifications.
Authors: Authors: Hunter NL, Awatramani RB, Farley FW, Dymecki SM.
View full abstract on Pubmed
Genetic mapping of the gene for a novel tyrosine kinase, Blk, to mouse chromosome 14.
Authors: Authors: Kozak CA, Dymecki SM, Niederhuber JE, Desiderio SV.
View full abstract on Pubmed
Correction: A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements.
Authors: Authors: Britz O, Zhang J, Grossmann KS, Dyck J, Kim JC, Dymecki S, Gosgnach S, Goulding M.
View full abstract on Pubmed
Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition.
Authors: Authors: Ray RS, Corcoran AE, Brust RD, Kim JC, Richerson GB, Nattie E, Dymecki SM.
View full abstract on Pubmed
The knockout mouse project.
Authors: Authors: Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B.
Nat Genet
View full abstract on Pubmed
Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells.
Authors: Authors: Dymecki SM, Niederhuber JE, Desiderio SV.
View full abstract on Pubmed
Activity of Raphé Serotonergic Neurons Controls Emotional Behaviors.
Authors: Authors: Teissier A, Chemiakine A, Inbar B, Bagchi S, Ray RS, Palmiter RD, Dymecki SM, Moore H, Ansorge MS.
Cell Rep
View full abstract on Pubmed