Susan Dymecki
Susan M. Dymecki, M.D.,Ph.D.
Professor of Genetics

The Dymecki lab studies how functional modularity arises within the brain serotonergic neuronal system and dynamically controls diverse processes ranging from respiration and thermal balance to emotional mood state to coping behaviors.

Understanding how this fundamental system develops at the molecular, cellular, and functional levels will help illuminate root causes of many brain disorders, paving the way for more targeted therapeutics and effective approaches to clinical conditions such as sudden infant death, major depression, and post-traumatic stress.

Using novel genetic tools for precision neural cell mapping in the mouse brain coupled with genomic, transcriptional, electrophysiological, and behavioral analyses, we examine the developmental specialization of subtypes of serotonin-producing neurons together with their network architecture, circuitry modulation, and selective roles in behavior. We probe how such neuronal diversity is generated and maintained, exploring the extent to which it is genetically programmed versus shaped by experience. Emerging is a neuronal structure-function map of substantial heterogeneity that suggests new ways to conceptualize and design treatments for serotonin-related disorders.

Serotonergic Modulation of Aggression in Drosophila Involves GABAergic and Cholinergic Opposing Pathways.
Authors: Authors: Alekseyenko OV, Chan YB, Okaty BW, Chang Y, Dymecki SM, Kravitz EA.
Curr Biol
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Multi-Scale Molecular Deconstruction of the Serotonin Neuron System.
Authors: Authors: Okaty BW, Freret ME, Rood BD, Brust RD, Hennessy ML, deBairos D, Kim JC, Cook MN, Dymecki SM.
Neuron
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Mapping cell fate and function using recombinase-based intersectional strategies.
Authors: Authors: Dymecki SM, Ray RS, Kim JC.
Methods Enzymol
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Cryptic boundaries in roof plate and choroid plexus identified by intersectional gene activation.
Authors: Authors: Awatramani R, Soriano P, Rodriguez C, Mai JJ, Dymecki SM.
Nat Genet
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A genetically defined asymmetry underlies the inhibitory control of flexor-extensor locomotor movements.
Authors: Authors: Britz O, Zhang J, Grossmann KS, Dyck J, Kim JC, Dymecki S, Gosgnach S, Goulding M.
Elife
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Rautenlippe Redux -- toward a unified view of the precerebellar rhombic lip.
Authors: Authors: Ray RS, Dymecki SM.
Curr Opin Cell Biol
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Switching on lineage tracers using site-specific recombination.
Authors: Authors: Dymecki SM, Rodriguez CI, Awatramani RB.
Methods Mol Biol
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cKit+ cardiac progenitors of neural crest origin.
Authors: Authors: Hatzistergos KE, Takeuchi LM, Saur D, Seidler B, Dymecki SM, Mai JJ, White IA, Balkan W, Kanashiro-Takeuchi RM, Schally AV, Hare JM.
Proc Natl Acad Sci U S A
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Linking genetically defined neurons to behavior through a broadly applicable silencing allele.
Authors: Authors: Kim JC, Cook MN, Carey MR, Shen C, Regehr WG, Dymecki SM.
Neuron
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An Flp indicator mouse expressing alkaline phosphatase from the ROSA26 locus.
Authors: Authors: Awatramani R, Soriano P, Mai JJ, Dymecki S.
Nat Genet
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