CHURCH LAB, Postdoctoral Fellow Opportunity: Computational biology for ancient DNA editing

April 2018

The Church lab has a funded opportunity for a postdoctoral scientist to further the development of the lab’s efforts for mammoth de-extinction and also aging research. The scientist in this position will be responsible for devising and optimizing sample preparation and sequencing library generation protocols and acquiring, validating, and analyzing DNA and RNA sequencing data from edited samples for the mammoth and aging research. Beyond these specific projects working in collaboration with two postdoctoral fellows in the lab, this scientist is expected to become a leading resource within the Church lab on analyzing ‘omics’ methods generally, who will consult and collaborate with others both within and outside of the lab on best ways of conducting and developing these exciting projects. The ideal candidate will have a demonstrated record of scientific rigor, ingenuity, and peer-reviewed publications, and be well-organized, self-motivated, and able to work well both in teams and alone.  Candidates should have a strong background and experience in computational aspects of high-throughput DNA and RNA sequencing, use of high-throughput omics data in the context of systems and/or synthetic biology projects, and a strong understanding of statistics. Experimental background is a plus but not required. Good oral and written communication skills are required.

Please include the following information in your cover letter:

Are you legally authorized to work in the United States? Will you now or in the future require sponsorship for employment visa status?

Email your cover letter and CV with the following reference code in the subject line:

Ref# DNA2018_Apr

To:   Eriona_Hysolli@hms.harvard.edu

Have any references sent directly from your referee to the same email address.

CHURCH LAB, Multiple Positions

April 2018

The Church lab has funded opportunities for postdoctoral scientists to advance two synthetic biology projects funded by the U.S. Department of Energy's (DOE) biofuel generation programs

Please answer the following questions below in your cover letter and include your CV and recommendations via email to church_lab_admin@hms.harvard.edu.

  1.  Are you legally authorized to work in the United States? Will you now or in the future require sponsorship for employment visa status?
  2.  What is your ideal scenario for a postdoc and beyond?

Postdoctoral Fellow in Translation Engineering:

The aim of one project is to conduct large-scale reengineering of the protein translation systems of E. coli strains whose genomes have been recoded so that one or more codons are unused, so that proteins containing multiple, distinct non-standard amino acids (NSAAs) (including D-amino acids) can be efficiently generated.  The scientist in this position will work with others in the lab to devise and implement ambitious strategies for developing, testing, demonstrating, and optimizing integrated sets of translation system components (such as tRNAs, amino-acyl tRNA synthetases, ribosomal proteins, rRNAs, and associated translation factors), that will operate together or in parallel in support of this goal.

Postdoctoral Fellow in Biosensor Development

The aim of the second project is use synthetic biology, structural biology, and protein engineering methods to alter existing proteins, or de novo design new ones, that respond efficiently and specifically in microbes to small molecules of potential importance or interest to DOE’s program.  The scientist in this position will leverage high-throughput computational biology, synthesis, and sequencing methods to generate and screen diverse libraries of biosensor proteins and optimize their products, in ways that either further advance techniques already developed or demonstrated by the lab or work towards new ones, and will also consider how NSAAs might be used in protein redesign. The scientists in either of these positions are expected to become leading resources within the Church lab on the general techniques and biology relevant to their projects, who will consult and work with others both within and outside of the lab on the best ways of leveraging these methods in related applications or towards other goals. The ideal candidates will have demonstrated records of scientific rigor, ingenuity, and peer-reviewed publications, and will be well-organized, self-motivated, and to work well both in teams and alone.  Candidates should be fast learners who have prior experience with sets of high throughput experimental and computational methods that are relevant to the positions for which they apply, should be familiar with high-throughput omics data analysis techniques, and should have a strong understanding of statistics.  Experience with technology development of new omics capabilities is highly desirable.  Excellent oral and written communication skills are required.
 

 

YANKER LAB, Multiple Positions

January 2018

Positions available to study gene regulation, epigenetics and the molecular biology of aging and neurodegenerative diseases.  Projects focus on iPS cells, C. elegans, animal models and the biology of genes involved in aging and Alzheimer's disease. For reference see: Nature 507:448, 2014, J. Cell Biol. 203:457, 2013, Mol. Cell 40:333, 2010, Nature 464:529, 2010, Nature 429:883, 2004. Experience in molecular biology is required.

Send CV, a brief description of research experience and names of 3 references to: Dr. Bruce Yankner by email to aharwick@genetics.med.harvard.edu

 


KIM LABAdministrative Associate II Job Description

August 2017

The Kim Lab in the Stem Cell Program at Boston Children’s Hospital is seeking an Administrative Associate II to support Dr. Carla Kim and her lab members. 

The Administrative Assistant II will be responsible for:

  • Providing administrative support to a principal investigator and her lab in the Stem Cell Program. This growing lab engages in stem cell biology and cancer research, with a focus on lung biology.
  • For the principal investigator, managing travel arrangements, maintaining financial records, overseeing grant submissions, managing calendar, managing lab projects, and providing customer service to her lab members.
  • Assisting with lab operations including the on boarding of new members and support of existing members.
  • Maintaining lab information including policies and procedures, databases and websites.

To qualify, you must have:

  • A high school level of educational development and six months of work experience. Bachelor’s degree is preferred.
  • Extensive experience with Microsoft suite of products, particularly Excel, Word and Outlook.
  • Initiative in improving operations within area/department, and the ability to assists in implementing changes.
  • No certification, registration or licensure required.

For more information or to apply to this position, please click here to access the Boston Children’s Hospital Career Site.  You may also contact Dr. Carla Kim directly at Carla.Kim@Childrens.Harvard.edu or 617-919-4865.