PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments.
Authors: Authors: Wang CY, Colognori D, Sunwoo H, Wang D, Lee JT.
Nat Commun
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Nat Commun
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Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X.
Authors: Authors: Colognori D, Sunwoo H, Kriz AJ, Wang CY, Lee JT.
Mol Cell
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Mol Cell
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Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition.
Authors: Authors: Del Rosario BC, Kriz AJ, Del Rosario AM, Anselmo A, Fry CJ, White FM, Sadreyev RI, Lee JT.
Elife
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Elife
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Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape.
Authors: Authors: Froberg JE, Pinter SF, Kriz AJ, Jégu T, Lee JT.
Nat Commun
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Nat Commun
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Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans.
Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development.
Authors: Authors: Matoba S, Wang H, Jiang L, Lu F, Iwabuchi KA, Wu X, Inoue K, Yang L, Press W, Lee JT, Ogura A, Shen L, Zhang Y.
Cell Stem Cell
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Cell Stem Cell
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Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.
Authors: Authors: Carrette LLG, Blum R, Ma W, Kelleher RJ, Lee JT.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X.
A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.
Authors: Authors: Carrette LLG, Wang CY, Wei C, Press W, Ma W, Kelleher RJ, Lee JT.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Genetic Intersection of Tsix and Hedgehog Signaling during the Initiation of X-Chromosome Inactivation.
Authors: Authors: Del Rosario BC, Del Rosario AM, Anselmo A, Wang PI, Sadreyev RI, Lee JT.
Dev Cell
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Dev Cell
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