Jonathan Seidman headshot

Jonathan G. Seidman, Ph.D.

Henrietta B. and Frederick H. Bugher Foundation Professor of Genetics
617-432-7830
Seidman Lab Website
Transcription factor protein interactomes reveal genetic determinants in heart disease.
Authors: Authors: Gonzalez-Teran B, Pittman M, Felix F, Thomas R, Richmond-Buccola D, Hüttenhain R, Choudhary K, Moroni E, Costa MW, Huang Y, Padmanabhan A, Alexanian M, Lee CY, Maven BEJ, Samse-Knapp K, Morton SU, McGregor M, Gifford CA, Seidman JG, Seidman CE, Gelb BD, Colombo G, Conklin BR, Black BL, Bruneau BG, Krogan NJ, Pollard KS, Srivastava D.
Cell
View full abstract on Pubmed
A functional genomic approach to actionable gene fusions for precision oncology.
Authors: Authors: Li J, Lu H, Ng PK, Pantazi A, Ip CKM, Jeong KJ, Amador B, Tran R, Tsang YH, Yang L, Song X, Dogruluk T, Ren X, Hadjipanayis A, Bristow CA, Lee S, Kucherlapati M, Parfenov M, Tang J, Seth S, Mahadeshwar HS, Mojumdar K, Zeng D, Zhang J, Protopopov A, Seidman JG, Creighton CJ, Lu Y, Sahni N, Shaw KR, Meric-Bernstam F, Futreal A, Chin L, Scott KL, Kucherlapati R, Mills GB, Liang H.
Sci Adv
View full abstract on Pubmed
Genome-Wide De Novo Variants in Congenital Heart Disease Are Not Associated With Maternal Diabetes or Obesity.
Authors: Authors: Morton SU, Pereira AC, Quiat D, Richter F, Kitaygorodsky A, Hagen J, Bernstein D, Brueckner M, Goldmuntz E, Kim RW, Lifton RP, Porter GA, Tristani-Firouzi M, Chung WK, Roberts A, Gelb BD, Shen Y, Newburger JW, Seidman JG, Seidman CE.
Circ Genom Precis Med
View full abstract on Pubmed
Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome.
Authors: Authors: Meier AB, Raj Murthi S, Rawat H, Toepfer CN, Santamaria G, Schmid M, Mastantuono E, Schwarzmayr T, Berutti R, Cleuziou J, Ewert P, Görlach A, Klingel K, Laugwitz KL, Seidman CE, Seidman JG, Moretti A, Wolf CM.
iScience
View full abstract on Pubmed
cruzi Infection in hiPSC-Derived Cardiomyocytes From Chagas Disease Patients With and Without Chronic Cardiomyopathy
Authors: Authors: Different Transcriptomic Response to T
Front Cell Infect Microbiol
View full abstract on Pubmed
Novel and Annotated Long Noncoding RNAs Associated with Ischemia in the Human Heart.
Authors: Authors: Ward Z, Schmeier S, Saddic L, Sigurdsson MI, Cameron VA, Pearson J, Miller A, Morley-Bunker A, Gorham J, Seidman JG, Moravec CS, Sweet WE, Aranki SF, Body S, Muehlschlegel JD, Pilbrow AP.
Int J Mol Sci
View full abstract on Pubmed
Plakophilin-2 truncating variants impair cardiac contractility by disrupting sarcomere stability and organization.
Authors: Authors: Zhang K, Cloonan PE, Sundaram S, Liu F, Das SL, Ewoldt JK, Bays JL, Tomp S, Toepfer CN, Marsiglia JDC, Gorham J, Reichart D, Eyckmans J, Seidman JG, Seidman CE, Chen CS.
Sci Adv
View full abstract on Pubmed
LAMP2 Cardiomyopathy: Consequences of Impaired Autophagy in the Heart.
Authors: Authors: Alcalai R, Arad M, Wakimoto H, Yadin D, Gorham J, Wang L, Burns E, Maron BJ, Roberts WC, Konno T, Conner DA, Perez-Atayde AR, Seidman JG, Seidman CE.
J Am Heart Assoc
View full abstract on Pubmed
Contribution of Noncanonical Splice Variants to TTN Truncating Variants Cardiomyopathy.
Authors: Authors: Patel PN, Ito K, Willcox JAL, Haghighi A, Jang MY, Gorham JM, DePalma SR, Lam L, McDonough B, Johnson R, Lakdawala NK, Roberts A, Barton PJR, Cook SA, Fatkin D, Seidman CE, Seidman JG.
Circ Genom Precis Med
View full abstract on Pubmed
Filamin C Cardiomyopathy Variants Cause Protein and Lysosome Accumulation.
Authors: Authors: Agarwal R, Paulo J, Toepfer CN, Ewoldt JK, Sundaram S, Chopra A, Zhang Q, Gorham J, DePalma S, Chen CS, Gygi S, Seidman CE, Seidman JG.
Circ Res
View full abstract on Pubmed