Jeannie Lee headshot

Jeannie T. Lee, M.D., Ph.D.

Professor of Genetics
617-726-5943
Lee Lab Website
Motif-driven interactions between RNA and PRC2 are rheostats that regulate transcription elongation.
Authors: Authors: Rosenberg M, Blum R, Kesner B, Aeby E, Garant JM, Szanto A, Lee JT.
Nat Struct Mol Biol
View full abstract on Pubmed
Decapping enzyme 1A breaks X-chromosome symmetry by controlling Tsix elongation and RNA turnover.
Authors: Authors: Aeby E, Lee HG, Lee YW, Kriz A, Del Rosario BC, Oh HJ, Boukhali M, Haas W, Lee JT.
Nat Cell Biol
View full abstract on Pubmed
Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment.
Authors: Authors: Colognori D, Sunwoo H, Wang D, Wang CY, Lee JT.
Dev Cell
View full abstract on Pubmed
Two- and three-color STORM analysis reveals higher-order assembly of leukotriene synthetic complexes on the nuclear envelope of murine neutrophils.
Authors: Authors: Schmider AB, Bauer NC, Sunwoo H, Godin MD, Ellis GE, Lee JT, Nigrovic PA, Soberman RJ.
J Biol Chem
View full abstract on Pubmed
Widespread organ tolerance to Xist loss and X reactivation except under chronic stress in the gut.
Authors: Authors: Yang L, Yildirim E, Kirby JE, Press W, Lee JT.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
Long Noncoding RNA Functionality Beyond Sequence: The Jpx Model: Commentary on "Functional Conservation of lncRNA JPX Despite Sequence and Structural Divergence" by Karner et al. (2019).
Authors: Authors: Oh HJ, Lee JT.
J Mol Biol
View full abstract on Pubmed
B2 and ALU retrotransposons are self-cleaving ribozymes whose activity is enhanced by EZH2.
Authors: Authors: Hernandez AJ, Zovoilis A, Cifuentes-Rojas C, Han L, Bujisic B, Lee JT.
Proc Natl Acad Sci U S A
View full abstract on Pubmed
The Firre locus produces a trans-acting RNA molecule that functions in hematopoiesis.
Authors: Authors: Lewandowski JP, Lee JC, Hwang T, Sunwoo H, Goldstein JM, Groff AF, Chang NP, Mallard W, Williams A, Henao-Meija J, Flavell RA, Lee JT, Gerhardinger C, Wagers AJ, Rinn JL.
Nat Commun
View full abstract on Pubmed
Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett syndrome.
Authors: Authors: Jagtap S, Thanos JM, Fu T, Wang J, Lalonde J, Dial TO, Feiglin A, Chen J, Kohane I, Lee JT, Sheridan SD, Perlis RH.
Hum Mol Genet
View full abstract on Pubmed
Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans.
Authors: Authors: Wang CY, Brand H, Shaw ND, Talkowski ME, Lee JT.
Genetics
View full abstract on Pubmed