Edward Benz, Jr., M.D.
Richard and Susan Smith Distinguished Professor of Medicine, Dana-Farber Cancer Institute
Professor of Genetics, Harvard Medical School
Professor of Pediatrics, Dana-Farber Cancer Institute
In erythrocytes, Protein 4.1R is essential for membrane integrity. Deficiencies cause congenital hemolytic anemia. We have shown that there are many isoforms of P4.1R in other tissues. These participate in the mitotic apparatus, costameres, tight junctions, and adherens junctions. We are studying the structure function relationships of these isoforms. We also study the regulated pre-mRNA splicing events that govern their tissue and differentiation stage expression. We have identified a novel splicing factor induced during erythropoiesis that is critical to regulated P4.1R splicing and have characterized the mechanism by which it alters splicing.
Commentary: troublesome words, linguistic precision, and medical oncology.
Novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection.
Authors: Authors: Zhou A, Ou AC, Cho A, Benz EJ, Huang SC.
Mol Cell Biol
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Mol Cell Biol
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Regulated Fox-2 isoform expression mediates protein 4.1R splicing during erythroid differentiation.
Paroxysmal nocturnal hemoglobinuria (PNH): an historical perspective.
Targeting the cell death-survival equation.
Authors: Authors: Benz EJ, Nathan DG, Amaravadi RK, Danial NN.
Clin Cancer Res
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Clin Cancer Res
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Development of an integrated approach to cancer disparities: one cancer center's experience.
Authors: Authors: Emmons KM, Burns White K, Benz EJ.
Cancer Epidemiol Biomarkers Prev
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Cancer Epidemiol Biomarkers Prev
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2006 Association of American Physicians George M. Kober Medal. Introduction of David G. Nathan, MD.
Partnerships with patients.
Restructuring the academic department of internal medicine.
An erythroid differentiation-specific splicing switch in protein 4.1R mediated by the interaction of SF2/ASF with an exonic splicing enhancer.