Stephen Elledge headshot

Stephen J. Elledge, Ph.D, Ph.D.

Gregor Mendel Professor of Genetics and of Medicine, Brigham and Women's Hospital
Professor of Medicine, Brigham and Women's Hospital
617-525-4510
Elledge Lab Website
The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation.
Authors: Authors: Martin TD, Patel RS, Cook DR, Choi MY, Patil A, Liang AC, Li MZ, Haigis KM, Elledge SJ.
Science
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CRISPR-based peptide library display and programmable microarray self-assembly for rapid quantitative protein binding assays.
Authors: Authors: Barber KW, Shrock E, Elledge SJ.
Mol Cell
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Coordinate regulation of the senescent state by selective autophagy.
Authors: Authors: Lee Y, Kim J, Kim MS, Kwon Y, Shin S, Yi H, Kim H, Chang MJ, Chang CB, Kang SB, Kim VN, Kim JH, Kim JS, Elledge SJ, Kang C.
Dev Cell
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ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
Authors: Authors: Mena EL, Donahue CJ, Vaites LP, Li J, Rona G, O'Leary C, Lignitto L, Miwatani-Minter B, Paulo JA, Dhabaria A, Ueberheide B, Gygi SP, Pagano M, Harper JW, Davey RA, Elledge SJ.
Proc Natl Acad Sci U S A
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Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality.
Authors: Authors: Morgenlander WR, Henson SN, Monaco DR, Chen A, Littlefield K, Bloch EM, Fujimura E, Ruczinski I, Crowley AR, Natarajan H, Butler SE, Weiner JA, Li MZ, Bonny TS, Benner SE, Balagopal A, Sullivan D, Shoham S, Quinn TC, Eshleman SH, Casadevall A, Redd AD, Laeyendecker O, Ackerman ME, Pekosz A, Elledge SJ, Robinson M, Tobian AA, Larman HB.
J Clin Invest
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Systematic characterization of mutations altering protein degradation in human cancers.
Authors: Authors: Tokheim C, Wang X, Timms RT, Zhang B, Mena EL, Wang B, Chen C, Ge J, Chu J, Zhang W, Elledge SJ, Brown M, Liu XS.
Mol Cell
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CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells.
Authors: Authors: Kumar S, Zeng Z, Bagati A, Tay RE, Sanz LA, Hartono SR, Ito Y, Abderazzaq F, Hatchi E, Jiang P, Cartwright ANR, Olawoyin O, Mathewson ND, Pyrdol JW, Li MZ, Doench JG, Booker MA, Tolstorukov MY, Elledge SJ, Chédin F, Liu XS, Wucherpfennig KW.
Cancer Discov
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Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.
Authors: Authors: Biering SB, Akey DL, Wong MP, Brown WC, Lo NTN, Puerta-Guardo H, Tramontini Gomes de Sousa F, Wang C, Konwerski JR, Espinosa DA, Bockhaus NJ, Glasner DR, Li J, Blanc SF, Juan EY, Elledge SJ, Mina MJ, Beatty PR, Smith JL, Harris E.
Science
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The uncharacterized SANT and BTB domain-containing protein SANBR inhibits class switch recombination.
Authors: Authors: Zheng S, Matthews AJ, Rahman N, Herrick-Reynolds K, Sible E, Choi JE, Wishnie A, Ng YK, Rhodes D, Elledge SJ, Vuong BQ.
J Biol Chem
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Antibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionality.
Authors: Authors: Morgenlander W, Henson S, Monaco D, Chen A, Littlefield K, Bloch EM, Fujimura E, Ruczinski I, Crowley AR, Natarajan H, Butler SE, Weiner JA, Li MZ, Bonny TS, Benner SE, Sullivan D, Shoham S, Quinn TC, Eshleman S, Casadevall A, Redd AD, Laeyendecker O, Ackerman ME, Pekosz A, Elledge SJ, Robinson M, Tobian AAR, Larman HB.
medRxiv
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