The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile.
Authors: Authors: Rajamuthiah R, Jayamani E, Majed H, Conery AL, Kim W, Kwon B, Fuchs BB, Kelso MJ, Ausubel FM, Mylonakis E.
Bioorg Med Chem Lett
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Bioorg Med Chem Lett
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Enhancing immunity by engineering DAMPs.
MICROBIOME. Plant microbiome blueprints.
A new antibiotic with potent activity targets MscL.
Authors: Authors: Iscla I, Wray R, Blount P, Larkins-Ford J, Conery AL, Ausubel FM, Ramu S, Kavanagh A, Huang JX, Blaskovich MA, Cooper MA, Obregon-Henao A, Orme I, Tjandra ES, Stroeher UH, Brown MH, Macardle C, van Holst N, Ling Tong C, Slattery AD, Gibson CT, Raston CL, Boulos RA.
J Antibiot (Tokyo)
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J Antibiot (Tokyo)
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Pathogen-secreted proteases activate a novel plant immune pathway.
Authors: Authors: Cheng Z, Li JF, Niu Y, Zhang XC, Woody OZ, Xiong Y, Djonovic S, Millet Y, Bush J, McConkey BJ, Sheen J, Ausubel FM.
Nature
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Nature
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Plant immunity triggered by engineered in vivo release of oligogalacturonides, damage-associated molecular patterns.
Authors: Authors: Benedetti M, Pontiggia D, Raggi S, Cheng Z, Scaloni F, Ferrari S, Ausubel FM, Cervone F, De Lorenzo G.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae.
Authors: Authors: Mammarella ND, Cheng Z, Fu ZQ, Daudi A, Bolwell GP, Dong X, Ausubel FM.
Phytochemistry
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Phytochemistry
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Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa.
Authors: Authors: Kirienko NV, Ausubel FM, Ruvkun G.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Insect-derived cecropins display activity against Acinetobacter baumannii in a whole-animal high-throughput Caenorhabditis elegans model.
Authors: Authors: Jayamani E, Rajamuthiah R, Larkins-Ford J, Fuchs BB, Conery AL, Vilcinskas A, Ausubel FM, Mylonakis E.
Antimicrob Agents Chemother
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Antimicrob Agents Chemother
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Associations with rhizosphere bacteria can confer an adaptive advantage to plants.