Inflammation and Alzheimer disease: the good, the bad, and the ugly.
Apoptosis in the nervous system.
Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1.
Authors: Authors: Zhang Z, Nadeau P, Song W, Donoviel D, Yuan M, Bernstein A, Yankner BA.
Nat Cell Biol
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Nat Cell Biol
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Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease.
Authors: Authors: Lorenzo A, Yuan M, Zhang Z, Paganetti PA, Sturchler-Pierrat C, Staufenbiel M, Mautino J, Vigo FS, Sommer B, Yankner BA.
Nat Neurosci
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Nat Neurosci
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A century of cognitive decline.
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta.
Authors: Authors: Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J.
Nature
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Nature
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The pathogenesis of Alzheimer's disease. Is amyloid beta-protein the beginning or the end?
Normal proteolytic processing of the presenilins.
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations.
Authors: Authors: Song W, Nadeau P, Yuan M, Yang X, Shen J, Yankner BA.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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Caspase activity sows the seeds of neuronal death.