Carla Kim headshot

Carla Kim, Ph.D.

Professor of Genetics

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information: https://www.childrenshospital.org/research/labs/kim-laboratory

Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis.
Authors: Authors: Lau AN, Curtis SJ, Fillmore CM, Rowbotham SP, Mohseni M, Wagner DE, Beede AM, Montoro DT, Sinkevicius KW, Walton ZE, Barrios J, Weiss DJ, Camargo FD, Wong KK, Kim CF.
EMBO J
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Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis.
Authors: Authors: Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF.
Cell
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Bone marrow-derived multipotent stromal cells attenuate inflammation in obliterative airway disease in mouse tracheal allografts.
Authors: Authors: Casey A, Dirks F, Liang OD, Harrach H, Schuette-Nuetgen K, Leeman K, Kim CF, Gerard C, Subramaniam M.
Stem Cells Int
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Lung stem and progenitor cells in tissue homeostasis and disease.
Authors: Authors: Leeman KT, Fillmore CM, Kim CF.
Curr Top Dev Biol
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Very small embryonic-like stem cells from the murine bone marrow differentiate into epithelial cells of the lung.
Authors: Authors: Kassmer SH, Jin H, Zhang PX, Bruscia EM, Heydari K, Lee JH, Kim CF, Kassmer SH, Krause DS, Krouse D.
Stem Cells
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Thrombospondin-1 mediates oncogenic Ras-induced senescence in premalignant lung tumors.
Authors: Authors: Baek KH, Bhang D, Zaslavsky A, Wang LC, Vachani A, Kim CF, Albelda SM, Evan GI, Ryeom S.
J Clin Invest
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Surfactant protein-C chromatin-bound green fluorescence protein reporter mice reveal heterogeneity of surfactant protein C-expressing lung cells.
Authors: Authors: Lee JH, Kim J, Gludish D, Roach RR, Saunders AH, Barrios J, Woo AJ, Chen H, Conner DA, Fujiwara Y, Stripp BR, Kim CF.
Am J Respir Cell Mol Biol
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The bed and the bugs: interactions between the tumor microenvironment and cancer stem cells.
Authors: Authors: CastaƱo Z, Fillmore CM, Kim CF, McAllister SS.
Semin Cancer Biol
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Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury.
Authors: Authors: Chen H, Matsumoto K, Brockway BL, Rackley CR, Liang J, Lee JH, Jiang D, Noble PW, Randell SH, Kim CF, Stripp BR.
Stem Cells
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Stem cells and regenerative medicine in lung biology and diseases.
Authors: Authors: Lau AN, Goodwin M, Kim CF, Weiss DJ.
Mol Ther
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