Carla Kim headshot

Carla Kim, Ph.D.

Principal Investigator, Boston Children’s Hospital
Stem Cell Program Faculty, Stem Cell Program
Professor of Genetics and Pediatrics, Harvard Medical School
617-919-4644
Kim Lab Website

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information: https://www.childrenshospital.org/research/labs/kim-laboratory

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
Authors: Authors: Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T.
Science
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Separating stem cells by flow cytometry: reducing variability for solid tissues.
Authors: Authors: Alexander CM, Puchalski J, Klos KS, Badders N, Ailles L, Kim CF, Dirks P, Smalley MJ.
Cell Stem Cell
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Commentary: Sca-1 and Cells of the Lung: A matter of Different Sorts.
Authors: Authors: Raiser DM, Kim CF.
Stem Cells
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Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.
Authors: Authors: Dovey JS, Zacharek SJ, Kim CF, Lees JA.
Proc Natl Acad Sci U S A
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Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration.
Authors: Authors: Nolen-Walston RD, Kim CF, Mazan MR, Ingenito EP, Gruntman AM, Tsai L, Boston R, Woolfenden AE, Jacks T, Hoffman AM.
Am J Physiol Lung Cell Mol Physiol
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Stem cell biology in the lung and lung cancers: using pulmonary context and classic approaches.
Authors: Authors: Raiser DM, Zacharek SJ, Roach RR, Curtis SJ, Sinkevicius KW, Gludish DW, Kim CF.
Cold Spring Harb Symp Quant Biol
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The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.
Authors: Authors: Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH.
Genes Dev
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Use of gene expression profiling to direct in vivo molecular imaging of lung cancer.
Authors: Authors: Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R.
Proc Natl Acad Sci U S A
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Identification of bronchioalveolar stem cells in normal lung and lung cancer.
Authors: Authors: Kim CF, Jackson EL, Woolfenden AE, Lawrence S, Babar I, Vogel S, Crowley D, Bronson RT, Jacks T.
Cell
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