Carla Kim headshot

Carla Kim, Ph.D.

Principal Investigator, Boston Children’s Hospital
Stem Cell Program Faculty, Stem Cell Program
Professor of Genetics and Pediatrics, Harvard Medical School
617-919-4644
Kim Lab Website

The broad interest of the Kim Lab is to characterize the biology of stem cells in normal lung and lung cancer. Numerous lung diseases such as cystic fibrosis or chronic obstructive pulmonary disease involve injured or depleted bronchiolar or alveolar epithelium. Bronchiolar and alveolar cells are also affected in adenocarcinoma, the most common form of lung cancer. It is likely that lung stem cells are critically affected in patients with these devastating diseases. Our long-term goal is to elucidate the role of stem cells in lung homeostasis as a prerequisite to the development of therapeutic strategies that can be used to prevent or attenuate lung disease.

Please see our website for more information: https://www.childrenshospital.org/research/labs/kim-laboratory

Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.
Authors: Authors: Yu M, Mazor T, Huang H, Huang HT, Kathrein KL, Woo AJ, Chouinard CR, Labadorf A, Akie TE, Moran TB, Xie H, Zacharek S, Taniuchi I, Roeder RG, Kim CF, Zon LI, Fraenkel E, Cantor AB.
Mol Cell
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Isolation and characterization of distal lung progenitor cells.
Authors: Authors: Driscoll B, Kikuchi A, Lau AN, Lee J, Reddy R, Jesudason E, Kim CF, Warburton D.
Methods Mol Biol
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Lung stem cell self-renewal relies on BMI1-dependent control of expression at imprinted loci.
Authors: Authors: Zacharek SJ, Fillmore CM, Lau AN, Gludish DW, Chou A, Ho JW, Zamponi R, Gazit R, Bock C, Jäger N, Smith ZD, Kim TM, Saunders AH, Wong J, Lee JH, Roach RR, Rossi DJ, Meissner A, Gimelbrant AA, Park PJ, Kim CF.
Cell Stem Cell
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Characterization of the cell of origin for small cell lung cancer.
Authors: Authors: Park KS, Liang MC, Raiser DM, Zamponi R, Roach RR, Curtis SJ, Walton Z, Schaffer BE, Roake CM, Zmoos AF, Kriegel C, Wong KK, Sage J, Kim CF.
Cell Cycle
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Primary tumor genotype is an important determinant in identification of lung cancer propagating cells.
Authors: Authors: Curtis SJ, Sinkevicius KW, Li D, Lau AN, Roach RR, Zamponi R, Woolfenden AE, Kirsch DG, Wong KK, Kim CF.
Cell Stem Cell
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Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice.
Authors: Authors: Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola KM, Nolen-Walston RD, Kim CF, Tsai L, Pierce RA, Mecham RP, Ingenito EP.
Am J Physiol Lung Cell Mol Physiol
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p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis.
Authors: Authors: Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T.
Science
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Separating stem cells by flow cytometry: reducing variability for solid tissues.
Authors: Authors: Alexander CM, Puchalski J, Klos KS, Badders N, Ailles L, Kim CF, Dirks P, Smalley MJ.
Cell Stem Cell
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Commentary: Sca-1 and Cells of the Lung: A matter of Different Sorts.
Authors: Authors: Raiser DM, Kim CF.
Stem Cells
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Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion.
Authors: Authors: Dovey JS, Zacharek SJ, Kim CF, Lees JA.
Proc Natl Acad Sci U S A
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