Constance Cepko headshot

Constance Cepko, Ph.D.

Bullard Professor of Genetics and Neuroscience, Harvard Medical School
Professor of Ophthalmology, Massachusetts Eye and Ear Infirmary
617-432-7618
Cepko Lab
Augmentation of CD47-SIRPa signaling protects cones in genetic models of retinal degeneration.
Authors: Authors: Wang SK, Xue Y, Cepko CL.
JCI Insight
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AAV-Txnip prolongs cone survival and vision in mouse models of retinitis pigmentosa.
Authors: Authors: Xue Y, Wang SK, Rana P, West ER, Hong CM, Feng H, Wu DM, Cepko CL.
Elife
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Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses.
Authors: Authors: Chan YK, Wang SK, Chu CJ, Copland DA, Letizia AJ, Costa Verdera H, Chiang JJ, Sethi M, Wang MK, Neidermyer WJ, Chan Y, Lim ET, Graveline AR, Sanchez M, Boyd RF, Vihtelic TS, Inciong RGCO, Slain JM, Alphonse PJ, Xue Y, Robinson-McCarthy LR, Tam JM, Jabbar MH, Sahu B, Adeniran JF, Muhuri M, Tai PWL, Xie J, Krause TB, Vernet A, Pezone M, Xiao R, Liu T, Wang W, Kaplan HJ, Gao G, Dick AD, Mingozzi F, McCall MA, Cepko CL, Church GM.
Sci Transl Med
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Clinical Assessment and Validation of a Rapid and Sensitive SARS-CoV-2 Test Using Reverse Transcription Loop-Mediated Isothermal Amplification Without the Need for RNA Extraction.
Authors: Authors: Anahtar MN, McGrath GEG, Rabe BA, Tanner NA, White BA, Lennerz JKM, Branda JA, Cepko CL, Rosenberg ES.
Open Forum Infect Dis
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Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa.
Authors: Authors: Wu DM, Ji X, Ivanchenko MV, Chung M, Piper M, Rana P, Wang SK, Xue Y, West E, Zhao SR, Xu H, Cicconet M, Xiong W, Cepko CL.
JCI Insight
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In Situ Detection of Adeno-associated Viral Vector Genomes with SABER-FISH.
Authors: Authors: Wang SK, Lapan SW, Hong CM, Krause TB, Cepko CL.
Mol Ther Methods Clin Dev
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SARS-CoV-2 detection using isothermal amplification and a rapid, inexpensive protocol for sample inactivation and purification.
Authors: Authors: Rabe BA, Cepko C.
Proc Natl Acad Sci U S A
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Probe-Seq: Method for RNA Sequencing of Specific Cell Types from Animal Tissue.
Authors: Authors: Amamoto R, Garcia MD, West ER, Choi J, Lapan SW, Lane EA, Perrimon N, Cepko CL.
Bio Protoc
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Microglia modulation by TGF-ß1 protects cones in mouse models of retinal degeneration.
Authors: Authors: Wang SK, Xue Y, Cepko CL.
J Clin Invest
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Cell type- and stage-specific expression of Otx2 is regulated by multiple transcription factors and cis-regulatory modules in the retina.
Authors: Authors: Chan CSY, Lonfat N, Zhao R, Davis AE, Li L, Wu MR, Lin CH, Ji Z, Cepko CL, Wang S.
Development
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