David Sinclair headshot

David Andrew Sinclair, Ph.D.

Professor of Genetics
Sinclair Lab Website
The 2021 FASEB science research conference on NAD metabolism and signaling.
Authors: Authors: Gorbunova V, Buschbeck M, Cambronne XA, Chellappa K, Corda D, Du J, Freichel M, Gigas J, Green AE, Gu F, Guberovic I, Jayabalan A, Khansahib I, Mukherjee S, Seluanov A, Simon MA, Sverkeli LJ, Kory N, Levine DC, Matic I, Nikiforov A, Rack JGM, Imai SI, Sinclair DA, Toiber D, Zhao Y, Mostoslavsky R, Kraus L, Guse AH.
Aging (Albany NY)
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Gut Microbiota Predicts Healthy Late-Life Aging in Male Mice.
Authors: Authors: Ke S, Mitchell SJ, MacArthur MR, Kane AE, Sinclair DA, Venable EM, Chadaideh KS, Carmody RN, Grodstein F, Mitchell JR, Liu Y.
Nutrients
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Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography.
Authors: Authors: Martínez-Greene JA, Hernández-Ortega K, Quiroz-Baez R, Resendis-Antonio O, Pichardo-Casas I, Sinclair DA, Budnik B, Hidalgo-Miranda A, Uribe-Querol E, Ramos-Godínez MDP, Martínez-Martínez E.
J Extracell Vesicles
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Measuring PGC-1a and Its Acetylation Status in Mouse Primary Myotubes.
Authors: Authors: Amorim JA, Sinclair DA.
Methods Mol Biol
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ARDD 2020: from aging mechanisms to interventions.
Authors: Authors: Mkrtchyan GV, Abdelmohsen K, Andreux P, Bagdonaite I, Barzilai N, Brunak S, Cabreiro F, de Cabo R, Campisi J, Cuervo AM, Demaria M, Ewald CY, Fang EF, Faragher R, Ferrucci L, Freund A, Silva-García CG, Georgievskaya A, Gladyshev VN, Glass DJ, Gorbunova V, de Grey A, He WW, Hoeijmakers J, Hoffmann E, Horvath S, Houtkooper RH, Jensen MK, Jensen MB, Kane A, Kassem M, de Keizer P, Kennedy B, Karsenty G, Lamming DW, Lee KF, MacAulay N, Mamoshina P, Mellon J, Molenaars M, Moskalev A, Mund A, Niedernhofer L, Osborne B, Pak HH, Parkhitko A, Raimundo N, Rando TA, Rasmussen LJ, Reis C, Riedel CG, Franco-Romero A, Schumacher B, Sinclair DA, Suh Y, Taub PR, Toiber D, Treebak JT, Valenzano DR, Verdin E, Vijg J, Young S, Zhang L, Bakula D, Zhavoronkov A, Scheibye-Knudsen M.
Aging (Albany NY)
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Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.
Authors: Authors: Chen X, Amorim JA, Moustafa GA, Lee JJ, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG.
Aging (Albany NY)
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Reprogramming to recover youthful epigenetic information and restore vision.
Authors: Authors: Lu Y, Brommer B, Tian X, Krishnan A, Meer M, Wang C, Vera DL, Zeng Q, Yu D, Bonkowski MS, Yang JH, Zhou S, Hoffmann EM, Karg MM, Schultz MB, Kane AE, Davidsohn N, Korobkina E, Chwalek K, Rajman LA, Church GM, Hochedlinger K, Gladyshev VN, Horvath S, Levine ME, Gregory-Ksander MS, Ksander BR, He Z, Sinclair DA.
Nature
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Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet.
Authors: Authors: Palliyaguru DL, Minor RK, Mitchell SJ, Palacios HH, Licata JJ, Ward TM, Abulwerdi G, Elliott P, Westphal C, Ellis JL, Sinclair DA, Price NL, Bernier M, de Cabo R.
J Gerontol A Biol Sci Med Sci
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Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty.
Authors: Authors: Schultz MB, Kane AE, Mitchell SJ, MacArthur MR, Warner E, Vogel DS, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA.
Nat Commun
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Age and life expectancy clocks based on machine learning analysis of mouse frailty.
Authors: Authors: Schultz MB, Kane AE, Mitchell SJ, MacArthur MR, Warner E, Vogel DS, Mitchell JR, Howlett SE, Bonkowski MS, Sinclair DA.
Nat Commun
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