David Andrew Sinclair

David Andrew Sinclair, Ph.D.

Professor of Genetics

Publications

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.

Authors: Authors: Armour SM, Bennett EJ, Braun CR, Zhang XY, McMahon SB, Gygi SP, Harper JW, Sinclair DA.
Mol Cell Biol 2013-04-01
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Evidence for a common mechanism of SIRT1 regulation by allosteric activators.

Authors: Authors: Hubbard BP, Gomes AP, Dai H, Li J, Case AW, Considine T, Riera TV, Lee JE, E SY, Lamming DW, Pentelute BL, Schuman ER, Stevens LA, Ling AJ, Armour SM, Michan S, Zhao H, Jiang Y, Sweitzer SM, Blum CA, Disch JS, Ng PY, Howitz KT, Rolo AP, Hamuro Y, Moss J, Perni RB, Ellis JL, Vlasuk GP, Sinclair DA.
Science 2013-03-08
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Identification of a SIRT1 mutation in a family with type 1 diabetes.

Authors: Authors: Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, Zulewski H, Geier A, Cermak JM, Elliott P, Ellis JL, Westphal C, Knobel U, Eloranta JJ, Kerr-Conte J, Pattou F, Konrad D, Matter CM, Fontana A, Rogler G, Schlapbach R, Regairaz C, Carballido JM, Glaser B, McBurney MW, Pociot F, Sinclair DA, Donath MY.
Cell Metab 2013-03-05
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cPLA2a knockout mice exhibit abnormalities in the architecture and synapses of cortical neurons.

Authors: Authors: Qu BX, Gong Y, Sinclair D, Fu M, Perl D, Diaz-Arrastia R.
Brain Res 2013-02-25
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Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene.

Authors: Authors: Han J, Hubbard BP, Lee J, Montagna C, Lee HW, Sinclair DA, Suh Y.
Cell Cycle 2013-01-15
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Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.

Authors: Authors: Strong R, Miller RA, Astle CM, Baur JA, de Cabo R, Fernandez E, Guo W, Javors M, Kirkland JL, Nelson JF, Sinclair DA, Teter B, Williams D, Zaveri N, Nadon NL, Harrison DE.
J Gerontol A Biol Sci Med Sci 2013-01-01
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World Health Organization guideline development: an evaluation.

Authors: Authors: Sinclair D, Isba R, Kredo T, Zani B, Smith H, Garner P.
PLoS One 2013-01-01
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Studying the replicative life span of yeast cells.

Authors: Authors: Sinclair DA.
Methods Mol Biol 2013-01-01
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Metformin improves healthspan and lifespan in mice.

Authors: Authors: Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R.
Nat Commun 2013-01-01
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µ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption.

Authors: Authors: Rouvinen-Lagerström N, Lahti J, Alho H, Kovanen L, Aalto M, Partonen T, Silander K, Sinclair D, Räikkönen K, Eriksson JG, Palotie A, Koskinen S, Saarikoski ST.
Alcohol Alcohol 2013-01-01
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