David Andrew Sinclair

David Andrew Sinclair, Ph.D.

Professor of Genetics

Publications

Constraints on nucleon decay via invisible modes from the Sudbury Neutrino Observatory.

Authors: Authors: Ahmed SN, Anthony AE, Beier EW, Bellerive A, Biller SD, Boger J, Boulay MG, Bowler MG, Bowles TJ, Brice SJ, Bullard TV, Chan YD, Chen M, Chen X, Cleveland BT, Cox GA, Dai X, Dalnoki-Veress F, Doe PJ, Dosanjh RS, Doucas G, Dragowsky MR, Duba CA, Duncan FA, Dunford M, Dunmore JA, Earle ED, Elliott SR, Evans HC, Ewan GT, Farine J, Fergani H, Fleurot F, Formaggio JA, Fowler MM, Frame K, Frati W, Fulsom BG, Gagnon N, Graham K, Grant DR, Hahn RL, Hall JC, Hallin AL, Hallman ED, Hamer AS, Handler WB, Hargrove CK, Harvey PJ, Hazama R, Heeger KM, Heintzelman WJ, Heise J, Helmer RL, Hemingway RJ, Hime A, Howe MA, Jagam P, Jelley NA, Klein JR, Kos MS, Krumins AV, Kutter T, Kyba CC, Labranche H, Lange R, Law J, Lawson IT, Lesko KT, Leslie JR, Levine I, Luoma S, MacLellan R, Majerus S, Mak HB, Maneira J, Marino AD, McCauley N, McDonald AB, McGee S, McGregor G, Mifflin C, Miknaitis KK, Miller GG, Moffat BA, Nally CW, Neubauer MS, Nickel BG, Noble AJ, Norman EB, Oblath NS, Okada CE, Ollerhead RW, Orrell JL, Oser SM, Ouellet C, Peeters SJ, Poon AW, Robertson BC, Robertson RG, Rollin E, Rosendahl SS, Rusu VL, Schwendener MH, Simard O, Simpson JJ, Sims CJ, Sinclair D, Skensved P, Smith MW, Starinsky N, Stokstad RG, Stonehill LC, Tafirout R, Takeuchi Y, Tesic G, Thomson M, Thorman M, Van Berg R, Van de Water RG, Virtue CJ, Wall BL, Waller D, Waltham CE, Tseung HW, Wark DL, West N, Wilhelmy JB, Wilkerson JF, Wilson JR, Wittich P, Wouters JM, Yeh M, Zuber K.
Phys Rev Lett 2004-03-12
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Yeast life-span extension by calorie restriction is independent of NAD fluctuation.

Authors: Authors: Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA.
Science 2003-12-19
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Cell biology. An age of instability.

Authors: Authors: Sinclair DA.
Science 2003-09-26
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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors: Authors: Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA.
Nature 2003-09-11
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Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin.

Authors: Authors: Bitterman KJ, Medvedik O, Sinclair DA.
Microbiol Mol Biol Rev 2003-09-01
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Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae.

Authors: Authors: Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA.
Nature 2003-05-08
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Is DNA cut out for a long life?

Authors: Authors: Sinclair D.
Sci Aging Knowledge Environ 2003-04-23
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Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.

Authors: Authors: Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.
J Biol Chem 2002-11-22
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Direct evidence for neutrino flavor transformation from neutral-current interactions in the Sudbury Neutrino Observatory.

Authors: Authors: Ahmad QR, Allen RC, Andersen TC, D Anglin J, Barton JC, Beier EW, Bercovitch M, Bigu J, Biller SD, Black RA, Blevis I, Boardman RJ, Boger J, Bonvin E, Boulay MG, Bowler MG, Bowles TJ, Brice SJ, Browne MC, Bullard TV, Bühler G, Cameron J, Chan YD, Chen HH, Chen M, Chen X, Cleveland BT, Clifford ET, Cowan JH, Cowen DF, Cox GA, Dai X, Dalnoki-Veress F, Davidson WF, Doe PJ, Doucas G, Dragowsky MR, Duba CA, Duncan FA, Dunford M, Dunmore JA, Earle ED, Elliott SR, Evans HC, Ewan GT, Farine J, Fergani H, Ferraris AP, Ford RJ, Formaggio JA, Fowler MM, Frame K, Frank ED, Frati W, Gagnon N, Germani JV, Gil S, Graham K, Grant DR, Hahn RL, Hallin AL, Hallman ED, Hamer AS, Hamian AA, Handler WB, Haq RU, Hargrove CK, Harvey PJ, Hazama R, Heeger KM, Heintzelman WJ, Heise J, Helmer RL, Hepburn JD, Heron H, Hewett J, Hime A, Howe M, Hykawy JG, Isaac MC, Jagam P, Jelley NA, Jillings C, Jonkmans G, Kazkaz K, Keener PT, Klein JR, Knox AB, Komar RJ, Kouzes R, Kutter T, Kyba CC, Law J, Lawson IT, Lay M, Lee HW, Lesko KT, Leslie JR, Levine I, Locke W, Luoma S, Lyon J, Majerus S, Mak HB, Maneira J, Manor J, Marino AD, McCauley N, McDonald AB, McDonald DS, McFarlane K, McGregor G, Meijer Drees R, Mifflin C, Miller GG, Milton G, Moffat BA, Moorhead M, Nally CW, Neubauer MS, Newcomer FM, Ng HS, Noble AJ, Norman EB, Novikov VM, O'Neill M, Okada CE, Ollerhead RW, Omori M, Orrell JL, Oser SM, Poon AW, Radcliffe TJ, Roberge A, Robertson BC, Robertson RG, Rosendahl SS, Rowley JK, Rusu VL, Saettler E, Schaffer KK, Schwendener MH, Schülke A, Seifert H, Shatkay M, Simpson JJ, Sims CJ, Sinclair D, Skensved P, Smith AR, Smith MW, Spreitzer T, Starinsky N, Steiger TD, Stokstad RG, Stonehill LC, Storey RS, Sur B, Tafirout R, Tagg N, Tanner NW, Taplin RK, Thorman M, Thornewell PM, Trent PT, Tserkovnyak YI, Van Berg R, Van de Water RG, Virtue CJ, Waltham CE, Wang JX, Wark DL, West N, Wilhelmy JB, Wilkerson JF, Wilson JR, Wittich P, Wouters JM, Yeh M.
Phys Rev Lett 2002-07-01
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Measurement of day and night neutrino energy spectra at SNO and constraints on neutrino mixing parameters.

Authors: Authors: Ahmad QR, Allen RC, Andersen TC, Anglin JD, Barton JC, Beier EW, Bercovitch M, Bigu J, Biller SD, Black RA, Blevis I, Boardman RJ, Boger J, Bonvin E, Boulay MG, Bowler MG, Bowles TJ, Brice SJ, Browne MC, Bullard TV, Bühler G, Cameron J, Chan YD, Chen HH, Chen M, Chen X, Cleveland BT, Clifford ET, Cowan JH, Cowen DF, Cox GA, Dai X, Dalnoki-Veress F, Davidson WF, Doe PJ, Doucas G, Dragowsky MR, Duba CA, Duncan FA, Dunford M, Dunmore JA, Earle ED, Elliott SR, Evans HC, Ewan GT, Farine J, Fergani H, Ferraris AP, Ford RJ, Formaggio JA, Fowler MM, Frame K, Frank ED, Frati W, Gagnon N, Germani JV, Gil S, Graham K, Grant DR, Hahn RL, Hallin AL, Hallman ED, Hamer AS, Hamian AA, Handler WB, Haq RU, Hargrove CK, Harvey PJ, Hazama R, Heeger KM, Heintzelman WJ, Heise J, Helmer RL, Hepburn JD, Heron H, Hewett J, Hime A, Howe M, Hykawy JG, Isaac MC, Jagam P, Jelley NA, Jillings C, Jonkmans G, Kazkaz K, Keener PT, Klein JR, Knox AB, Komar RJ, Kouzes R, Kutter T, Kyba CC, Law J, Lawson IT, Lay M, Lee HW, Lesko KT, Leslie JR, Levine I, Locke W, Luoma S, Lyon J, Majerus S, Mak HB, Maneira J, Manor J, Marino AD, McCauley N, McDonald AB, McDonald DS, McFarlane K, McGregor G, Meijer Drees R, Mifflin C, Miller GG, Milton G, Moffat BA, Moorhead M, Nally CW, Neubauer MS, Newcomer FM, Ng HS, Noble AJ, Norman EB, Novikov VM, O'Neill M, Okada CE, Ollerhead RW, Omori M, Orrell JL, Oser SM, Poon AW, Radcliffe TJ, Roberge A, Robertson BC, Robertson RG, Rosendahl SS, Rowley JK, Rusu VL, Saettler E, Schaffer KK, Schwendener MH, Schülke A, Seifert H, Shatkay M, Simpson JJ, Sims CJ, Sinclair D, Skensved P, Smith AR, Smith MW, Spreitzer T, Starinsky N, Steiger TD, Stokstad RG, Stonehill LC, Storey RS, Sur B, Tafirout R, Tagg N, Tanner NW, Taplin RK, Thorman M, Thornewell PM, Trent PT, Tserkovnyak YI, Van Berg R, Van de Water RG, Virtue CJ, Waltham CE, Wang JX, Wark DL, West N, Wilhelmy JB, Wilkerson JF, Wilson JR, Wittich P, Wouters JM, Yeh M.
Phys Rev Lett 2002-07-01
View full abstract on Pubmed