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David Andrew Sinclair, Ph.D.

Professor of Genetics
The light gene of Drosophila melanogaster encodes a homologue of VPS41, a yeast gene involved in cellular-protein trafficking.
Authors: Authors: Warner TS, Sinclair DA, Fitzpatrick KA, Singh M, Devlin RH, Honda BM.
Genome
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The Additional sex combs gene of Drosophila encodes a chromatin protein that binds to shared and unique Polycomb group sites on polytene chromosomes.
Authors: Authors: Sinclair DA, Milne TA, Hodgson JW, Shellard J, Salinas CA, Kyba M, Randazzo F, Brock HW.
Development
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Characterization of a Drosophila homologue of the 160-kDa subunit of the cleavage and polyadenylation specificity factor CPSF.
Authors: Authors: Salinas CA, Sinclair DA, O'Hare K, Brock HW.
Mol Gen Genet
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Molecular mechanisms of yeast aging.
Authors: Authors: Sinclair DA, Mills K, Guarente L.
Trends Biochem Sci
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Enhancer of Polycomb is a suppressor of position-effect variegation in Drosophila melanogaster.
Authors: Authors: Sinclair DA, Clegg NJ, Antonchuk J, Milne TA, Stankunas K, Ruse C, Grigliatti TA, Kassis JA, Brock HW.
Genetics
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Aging in Saccharomyces cerevisiae.
Authors: Authors: Sinclair D, Mills K, Guarente L.
Annu Rev Microbiol
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Extrachromosomal rDNA circles--a cause of aging in yeast.
Authors: Authors: Sinclair DA, Guarente L.
Cell
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Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants.
Authors: Authors: Sinclair DA, Mills K, Guarente L.
Science
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Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.
Authors: Authors: Kennedy BK, Gotta M, Sinclair DA, Mills K, McNabb DS, Murthy M, Pak SM, Laroche T, Gasser SM, Guarente L.
Cell
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Competition between different variegating rearrangements for limited heterochromatic factors in Drosophila melanogaster.
Authors: Authors: Lloyd VK, Sinclair DA, Grigliatti TA.
Genetics
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