Edward J. Benz headshot
Edward Benz, Jr., M.D.
Richard and Susan Smith Distinguished Professor of Medicine, Dana-Farber Cancer Institute
Professor of Genetics, Harvard Medical School
Professor of Pediatrics, Dana-Farber Cancer Institute

In erythrocytes, Protein 4.1R is essential for membrane integrity. Deficiencies cause congenital hemolytic anemia. We have shown that there are many isoforms of P4.1R in other tissues. These participate in the mitotic apparatus, costameres, tight junctions, and adherens junctions. We are studying the structure function relationships of these isoforms. We also study the regulated pre-mRNA splicing events that govern their tissue and differentiation stage expression. We have identified a novel splicing factor induced during erythropoiesis that is critical to regulated P4.1R splicing and have characterized the mechanism by which it alters splicing.

Advancing the Science of Healthcare Service Delivery: The NHLBI Corporate Healthcare Leaders' Panel.
Authors: Authors: Sampson UKA, McGlynn EA, Perlin JB, Frisse ME, Arnold SB, Benz EJ, Brennan T, Briss P, Beeuwkes Buntin MJ, Khosla S, King RG, Kuntz R, Leider H, Ling SM, Macrae J, Murray R, Thrailkill E, Wager C, Witchey D, Jacobson HR.
Glob Heart
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Breakthrough Therapy Designation for New Drugs.
Authors: Authors: Benz EJ.
JAMA
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Protein 4.1R Exon 16 3' Splice Site Activation Requires Coordination among TIA1, Pcbp1, and RBM39 during Terminal Erythropoiesis.
Authors: Authors: Huang SC, Zhang HS, Yu B, McMahon E, Nguyen DT, Yu FH, Ou AC, Ou JP, Benz EJ.
Mol Cell Biol
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The Jeremiah Metzger Lecture Cancer in the Twenty-First Century: An Inside View from an Outsider.
Authors: Authors: Benz EJ.
Trans Am Clin Climatol Assoc
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Protein 4.1R Influences Myogenin Protein Stability and Skeletal Muscle Differentiation.
Authors: Authors: Huang SC, Zhou A, Nguyen DT, Zhang HS, Benz EJ.
J Biol Chem
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Value, Access, and Cost of Cancer Care Delivery at Academic Cancer Centers.
Authors: Authors: Nardi EA, Wolfson JA, Rosen ST, Diasio RB, Gerson SL, Parker BA, Alvarnas JC, Levine HA, Fong Y, Weisenburger DD, Fitzgerald CL, Egan M, Stranford S, Carlson RW, Benz EJ.
J Natl Compr Canc Netw
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BERNARD GREGOIRE FORGET, MD: 1939 - 2015.
Authors: Authors: Benz EJ.
Trans Am Clin Climatol Assoc
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In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.
Authors: Authors: Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA.
Mayo Clin Proc
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A tribute to Emil Frei III.
Authors: Authors: Benz EJ, Nathan DG.
J Clin Invest
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Presidential address: doing our part to ensure the future of academic medicine.
Authors: Authors: Benz EJ.
Trans Am Clin Climatol Assoc
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