Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Linear RAG scanning mediates editing of Ig? variable region repertoires.
Authors: Authors: Li X, Hu H, Zhang Y, Zhu T, Guan Y, Xu K, Lin X, Hebert C, Batra H, Zhou J, Ba Z, Wesemann DR, Ye AY, Alt FW.
Nature
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Author Correction: Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors.
Authors: Authors: Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, Alt FW, Lichter P, Ernst A.
Nat Commun
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Recurrent SARS-CoV-2 Omicron broadly neutralizing humanized antibodies in different single human VH1-2-rearranging mouse models.
Authors: Authors: Batra H, Luo S, Saunders KO, Higgins JS, Jian F, Zhang J, Kibria MG, Jonaid GM, Zhou QJ, Eaton A, Cronin K, Mallory ML, Mattocks M, Edwards RJ, Parks R, Lee EM, Ye AY, Williams AC, Jung G, Mansouri K, Alam SM, Montefiori DC, Tian M, Baric RS, Cao Y, Haynes BF, Chen B, Alt FW.
Proc Natl Acad Sci U S A
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Epigenetic changes by EZH2 inhibition increase translocations in B cells with high AID activity or DNA repair deficiency.
Authors: Authors: Tao J, Alessandri L, Gasparetto A, Zhao L, Zhang X, Alt FW, Chiarle R.
Blood
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Editorial Expression of Concern: Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.
Authors: Authors: Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA.
Nature
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An engineered immunogen activates diverse HIV broadly neutralizing antibody precursors and promotes acquisition of improbable mutations.
Authors: Authors: Swanson OM, Zhang QE, Van Itallie E, Tian M, Brown AR, Harris C, Kapingidza AB, Rhodes B, Smith LM, Venkatayogi S, Cronin K, Frazier M, Parks R, Bar M, Jiang C, Martin Beem JS, Cheng HL, Davis J, McGovern K, Newman A, Edwards RJ, Cain D, Alam SM, Wiehe K, Saunders KO, Acharya P, Alt F, Haynes BF, Azoitei ML.
Sci Transl Med
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Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies.
Authors: Authors: Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF.
Nat Commun
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Orientation Regulation of Class-switch Recombination in Human B Cells.
Authors: Authors: Du L, Oksenych V, Wan H, Ye X, Dong J, Ye AY, Abolhassani H, Vlachiotis S, Zhang X, de la Rosa K, Hammarström L, van der Burg M, Alt FW, Pan-Hammarström Q.
J Immunol
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Comparison of the immunogenicity of mRNA-encoded and protein HIV-1 Env-ferritin nanoparticle designs.
Authors: Authors: Mu Z, Whitley J, Martik D, Sutherland L, Newman A, Barr M, Parks R, Wiehe K, Cain DW, Hodges KZ, Venkatayogi S, Lee EM, Smith L, Mansouri K, Edwards RJ, Wang Y, Rountree W, Alameh M-G, Tam Y, Barbosa C, Tomai M, Lewis MG, Santrai S, Maughan M, Tian M, Alt FW, Weissman D, Saunders KO, Haynes BF.
J Virol
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Germline-targeting HIV vaccination induces neutralizing antibodies to the CD4 binding site.
Authors: Authors: Caniels TG, Medina-Ramìrez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sánchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW.
Sci Immunol
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