Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen.

Authors: Authors: Bry L, Brenner MB.
J Immunol 2004-01-01
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CD1: antigen presentation and T cell function.

Authors: Authors: Brigl M, Brenner MB.
Annu Rev Immunol 2004-01-01
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Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

Authors: Authors: Talukder SR, Dudley DD, Alt FW, Takahama Y, Akamatsu Y.
Nucleic Acids Res 2004-01-01
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Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.

Authors: Authors: Brenner MB, Gromada J, Efanov AM, Bokvist K, Mest HJ.
Ann N Y Acad Sci 2003-12-01
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Mechanism of CD1d-restricted natural killer T cell activation during microbial infection.

Authors: Authors: Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB.
Nat Immunol 2003-12-01
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Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.

Authors: Authors: Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS.
Int Immunol 2003-12-01
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Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.

Authors: Authors: Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH.
Mol Cell 2003-12-01
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Innate immune response to encephalomyocarditis virus infection mediated by CD1d.

Authors: Authors: Exley MA, Bigley NJ, Cheng O, Shaulov A, Tahir SM, Carter QL, Garcia J, Wang C, Patten K, Stills HF, Alt FW, Snapper SB, Balk SP.
Immunology 2003-12-01
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Structural features of the acyl chain determine self-phospholipid antigen recognition by a CD1d-restricted invariant NKT (iNKT) cell.

Authors: Authors: Rauch J, Gumperz J, Robinson C, Sköld M, Roy C, Young DC, Lafleur M, Moody DB, Brenner MB, Costello CE, Behar SM.
J Biol Chem 2003-11-28
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Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.

Authors: Authors: Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, Fredericks J, Nishi S, Mildiner S, Moores SL, Brugge J, Rosen FS, Swat W.
J Exp Med 2003-11-17
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