Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Mechanism of CD1d-restricted natural killer T cell activation during microbial infection.

Authors: Authors: Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB.
Nat Immunol 2003-12-01
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Impaired signaling via the high-affinity IgE receptor in Wiskott-Aldrich syndrome protein-deficient mast cells.

Authors: Authors: Pivniouk VI, Snapper SB, Kettner A, Alenius H, Laouini D, Falet H, Hartwig J, Alt FW, Geha RS.
Int Immunol 2003-12-01
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Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice.

Authors: Authors: Theunissen JW, Kaplan MI, Hunt PA, Williams BR, Ferguson DO, Alt FW, Petrini JH.
Mol Cell 2003-12-01
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Innate immune response to encephalomyocarditis virus infection mediated by CD1d.

Authors: Authors: Exley MA, Bigley NJ, Cheng O, Shaulov A, Tahir SM, Carter QL, Garcia J, Wang C, Patten K, Stills HF, Alt FW, Snapper SB, Balk SP.
Immunology 2003-12-01
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Structural features of the acyl chain determine self-phospholipid antigen recognition by a CD1d-restricted invariant NKT (iNKT) cell.

Authors: Authors: Rauch J, Gumperz J, Robinson C, Sköld M, Roy C, Young DC, Lafleur M, Moody DB, Brenner MB, Costello CE, Behar SM.
J Biol Chem 2003-11-28
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Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells.

Authors: Authors: Fujikawa K, Miletic AV, Alt FW, Faccio R, Brown T, Hoog J, Fredericks J, Nishi S, Mildiner S, Moores SL, Brugge J, Rosen FS, Swat W.
J Exp Med 2003-11-17
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Flexible migration program regulates gamma delta T-cell involvement in humoral immunity.

Authors: Authors: Brandes M, Willimann K, Lang AB, Nam KH, Jin C, Brenner MB, Morita CT, Moser B.
Blood 2003-11-15
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Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice.

Authors: Authors: Dudley DD, Sekiguchi J, Zhu C, Sadofsky MJ, Whitlow S, DeVido J, Monroe RJ, Bassing CH, Alt FW.
J Exp Med 2003-11-03
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Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.

Authors: Authors: Cernadas M, Sugita M, van der Wel N, Cao X, Gumperz JE, Maltsev S, Besra GS, Behar SM, Peters PJ, Brenner MB.
J Immunol 2003-10-15
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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice.

Authors: Authors: Cheng HL, Mostoslavsky R, Saito S, Manis JP, Gu Y, Patel P, Bronson R, Appella E, Alt FW, Chua KF.
Proc Natl Acad Sci U S A 2003-09-16
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