Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Notch signalling drives synovial fibroblast identity and arthritis pathology.
Authors: Authors: Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB.
Nature
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BCR selection and affinity maturation in Peyer's patch germinal centres.
Authors: Authors: Chen H, Zhang Y, Ye AY, Du Z, Xu M, Lee CS, Hwang JK, Kyritsis N, Ba Z, Neuberg D, Littman DR, Alt FW.
Nature
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Induction of recurrent break cluster genes in neural progenitor cells differentiated from embryonic stem cells in culture.
Authors: Authors: Tena A, Zhang Y, Kyritsis N, Devorak A, Zurita J, Wei PC, Alt FW.
Proc Natl Acad Sci U S A
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Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Authors: Authors: Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL.
Proc Natl Acad Sci U S A
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Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models.
Authors: Authors: Tian M, McGovern K, Cheng HL, Waddicor P, Rieble L, Dao M, Chen Y, Kimble MT, Cantor E, Manfredonia N, Judson R, Chapdelaine-Williams A, Cain DW, Haynes BF, Alt FW.
Proc Natl Acad Sci U S A
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A Two-Cell Model for IL-1ß Release Mediated by Death-Receptor Signaling.
Authors: Authors: Donado CA, Cao AB, Simmons DP, Croker BA, Brennan PJ, Brenner MB.
Cell Rep
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CUX1 and I?B? (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts.
Authors: Authors: Slowikowski K, Nguyen HN, Noss EH, Simmons DP, Mizoguchi F, Watts GFM, Gurish MF, Brenner MB, Raychaudhuri S.
Proc Natl Acad Sci U S A
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Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci.
Authors: Authors: Gutierrez-Arcelus M, Baglaenko Y, Arora J, Hannes S, Luo Y, Amariuta T, Teslovich N, Rao DA, Ermann J, Jonsson AH, Navarrete C, Rich SS, Taylor KD, Rotter JI, Gregersen PK, Esko T, Brenner MB, Raychaudhuri S.
Nat Genet
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Immune checkpoint modulation enhances HIV-1 antibody induction.
Authors: Authors: Bradley T, Kuraoka M, Yeh CH, Tian M, Chen H, Cain DW, Chen X, Cheng C, Ellebedy AH, Parks R, Barr M, Sutherland LL, Scearce RM, Bowman CM, Bouton-Verville H, Santra S, Wiehe K, Lewis MG, Ogbe A, Borrow P, Montefiori D, Bonsignori M, Anthony Moody M, Verkoczy L, Saunders KO, Ahmed R, Mascola JR, Kelsoe G, Alt FW, Haynes BF.
Nat Commun
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Increased Neural Progenitor Proliferation in a hiPSC Model of Autism Induces Replication Stress-Associated Genome Instability.
Authors: Authors: Wang M, Wei PC, Lim CK, Gallina IS, Marshall S, Marchetto MC, Alt FW, Gage FH.
Cell Stem Cell
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