Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Identification of shared antigenic determinants of the putative human T lymphocyte antigen receptor.

Authors: Authors: Brenner MB, Trowbridge IS, McLean J, Strominger JL.
J Exp Med 1984-08-01
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Ordered rearrangement of immunoglobulin heavy chain variable region segments.

Authors: Authors: Alt FW, Yancopoulos GD, Blackwell TK, Wood C, Thomas E, Boss M, Coffman R, Rosenberg N, Tonegawa S, Baltimore D.
EMBO J 1984-06-01
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Site-specific recombination between immunoglobulin D and JH segments that were introduced into the genome of a murine pre-B cell line.

Authors: Authors: Blackwell TK, Alt FW.
Cell 1984-05-01
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Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells.

Authors: Authors: Hemler ME, Brenner MB, McLean JM, Strominger JL.
Proc Natl Acad Sci U S A 1984-04-01
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In vitro T lymphocyte proliferative response to Yersinia enterocolitica in Reiter's syndrome. Lack of response in other HLA-B27 positive individuals.

Authors: Authors: Brenner MB, Kobayashi S, Wiesenhutter CW, Huberman AK, Bales P, Yu DT.
Arthritis Rheum 1984-03-01
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Transposition and amplification of oncogene-related sequences in human neuroblastomas.

Authors: Authors: Kohl NE, Kanda N, Schreck RR, Bruns G, Latt SA, Gilbert F, Alt FW.
Cell 1983-12-01
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Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.

Authors: Authors: Kanda N, Schreck R, Alt F, Bruns G, Baltimore D, Latt S.
Proc Natl Acad Sci U S A 1983-07-01
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Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus.

Authors: Authors: Lewis S, Rosenberg N, Alt F, Baltimore D.
Cell 1982-10-01
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Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

Authors: Authors: Alt FW, Baltimore D.
Proc Natl Acad Sci U S A 1982-07-01
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Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.

Authors: Authors: Alt FW, Rosenberg N, Enea V, Siden E, Baltimore D.
Mol Cell Biol 1982-04-01
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