Frederick Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital

Professor of Genetics, Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells.

Authors: Authors: Hemler ME, Brenner MB, McLean JM, Strominger JL.
Proc Natl Acad Sci U S A 1984-04-01
View full abstract on Pubmed

In vitro T lymphocyte proliferative response to Yersinia enterocolitica in Reiter's syndrome. Lack of response in other HLA-B27 positive individuals.

Authors: Authors: Brenner MB, Kobayashi S, Wiesenhutter CW, Huberman AK, Bales P, Yu DT.
Arthritis Rheum 1984-03-01
View full abstract on Pubmed

Transposition and amplification of oncogene-related sequences in human neuroblastomas.

Authors: Authors: Kohl NE, Kanda N, Schreck RR, Bruns G, Latt SA, Gilbert F, Alt FW.
Cell 1983-12-01
View full abstract on Pubmed

Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes.

Authors: Authors: Kanda N, Schreck R, Alt F, Bruns G, Baltimore D, Latt S.
Proc Natl Acad Sci U S A 1983-07-01
View full abstract on Pubmed

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus.

Authors: Authors: Lewis S, Rosenberg N, Alt F, Baltimore D.
Cell 1982-10-01
View full abstract on Pubmed

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

Authors: Authors: Alt FW, Baltimore D.
Proc Natl Acad Sci U S A 1982-07-01
View full abstract on Pubmed

Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.

Authors: Authors: Alt FW, Rosenberg N, Enea V, Siden E, Baltimore D.
Mol Cell Biol 1982-04-01
View full abstract on Pubmed

Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line.

Authors: Authors: Alt FW, Rosenberg N, Casanova RJ, Thomas E, Baltimore D.
Nature 1982-03-25
View full abstract on Pubmed

Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes.

Authors: Authors: Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore D.
Cell 1981-12-01
View full abstract on Pubmed

Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.

Authors: Authors: Siden E, Alt FW, Shinefeld L, Sato V, Baltimore D.
Proc Natl Acad Sci U S A 1981-03-01
View full abstract on Pubmed