Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virus.
Authors: Authors: Lewis S, Rosenberg N, Alt F, Baltimore D.
Cell
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Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.
Authors: Authors: Alt FW, Baltimore D.
Proc Natl Acad Sci U S A
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Multiple immunoglobulin heavy-chain gene transcripts in Abelson murine leukemia virus-transformed lymphoid cell lines.
Authors: Authors: Alt FW, Rosenberg N, Enea V, Siden E, Baltimore D.
Mol Cell Biol
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Immunoglobulin heavy-chain expression and class switching in a murine leukaemia cell line.
Authors: Authors: Alt FW, Rosenberg N, Casanova RJ, Thomas E, Baltimore D.
Nature
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Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes.
Authors: Authors: Alt F, Rosenberg N, Lewis S, Thomas E, Baltimore D.
Cell
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Synthesis of immunoglobulin mu chain gene products precedes synthesis of light chains during B-lymphocyte development.
Authors: Authors: Siden E, Alt FW, Shinefeld L, Sato V, Baltimore D.
Proc Natl Acad Sci U S A
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Expression of J chain RNA in cell lines representing different stages of B lymphocyte differentiation.
Authors: Authors: Mather EL, Alt FW, Bothwell AL, Baltimore D, Koshland ME.
Cell
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Activity of multiple light chain genes in murine myeloma cells producing a single, functional light chain.
Authors: Authors: Alt FW, Enea V, Bothwell AL, Baltimore D.
Cell
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Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends.
Authors: Authors: Alt FW, Bothwell AL, Knapp M, Siden E, Mather E, Koshland M, Baltimore D.
Cell
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Amplification of dihydrofolate reductase genes in methotrexate-resistant cultured mouse cells.
Authors: Authors: Schimke RT, Alt FW, Kellems RE, Kaufman RJ, Bertino JR.
Cold Spring Harb Symp Quant Biol
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