Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Parp3 promotes long-range end joining in murine cells.
Authors: Authors: Layer JV, Cleary JP, Brown AJ, Stevenson KE, Morrow SN, Van Scoyk A, Blasco RB, Karaca E, Meng FL, Frock RL, Tivey T, Kim S, Fuchs H, Chiarle R, Alt FW, Roberts SA, Weinstock DM, Day TA.
Proc Natl Acad Sci U S A
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Guiding a mutator in antibody diversification.
Authors: Authors: Tian M, Alt FW.
Cell Res
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Innate T Cells Govern Adipose Tissue Biology.
Authors: Authors: LaMarche NM, Kohlgruber AC, Brenner MB.
J Immunol
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Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination.
Authors: Authors: Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S.
Proc Natl Acad Sci U S A
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Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies.
Authors: Authors: Duan H, Chen X, Boyington JC, Cheng C, Zhang Y, Jafari AJ, Stephens T, Tsybovsky Y, Kalyuzhniy O, Zhao P, Menis S, Nason MC, Normandin E, Mukhamedova M, DeKosky BJ, Wells L, Schief WR, Tian M, Alt FW, Kwong PD, Mascola JR.
Immunity
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DNA melting initiates the RAG catalytic pathway.
Authors: Authors: Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H.
Nat Struct Mol Biol
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High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction.
Authors: Authors: Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra HJ, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA.
Nat Genet
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CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning.
Authors: Authors: Jain S, Ba Z, Zhang Y, Dai HQ, Alt FW.
Cell
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Lysosome-Mediated Plasma Membrane Repair Is Dependent on the Small GTPase Arl8b and Determines Cell Death Type in Mycobacterium tuberculosis Infection.
Authors: Authors: Michelet X, Tuli A, Gan H, Geadas C, Sharma M, Remold HG, Brenner MB.
J Immunol
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?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.
Authors: Authors: Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L.
Nat Immunol
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