Frederick W. Alt

Frederick Alt, Ph.D.

Charles A. Janeway Professor of Pediatrics, Boston Children's Hospital
Professor of Genetics, Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Kinase-dependent structural role of DNA-PKcs during immunoglobulin class switch recombination.
Authors: Authors: Crowe JL, Shao Z, Wang XS, Wei PC, Jiang W, Lee BJ, Estes VM, Alt FW, Zha S.
Proc Natl Acad Sci U S A
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Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies.
Authors: Authors: Duan H, Chen X, Boyington JC, Cheng C, Zhang Y, Jafari AJ, Stephens T, Tsybovsky Y, Kalyuzhniy O, Zhao P, Menis S, Nason MC, Normandin E, Mukhamedova M, DeKosky BJ, Wells L, Schief WR, Tian M, Alt FW, Kwong PD, Mascola JR.
Immunity
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High-throughput identification of noncoding functional SNPs via type IIS enzyme restriction.
Authors: Authors: Li G, Martínez-Bonet M, Wu D, Yang Y, Cui J, Nguyen HN, Cunin P, Levescot A, Bai M, Westra HJ, Okada Y, Brenner MB, Raychaudhuri S, Hendrickson EA, Maas RL, Nigrovic PA.
Nat Genet
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DNA melting initiates the RAG catalytic pathway.
Authors: Authors: Ru H, Mi W, Zhang P, Alt FW, Schatz DG, Liao M, Wu H.
Nat Struct Mol Biol
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CTCF-Binding Elements Mediate Accessibility of RAG Substrates During Chromatin Scanning.
Authors: Authors: Jain S, Ba Z, Zhang Y, Dai HQ, Alt FW.
Cell
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?d T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis.
Authors: Authors: Kohlgruber AC, Gal-Oz ST, LaMarche NM, Shimazaki M, Duquette D, Koay HF, Nguyen HN, Mina AI, Paras T, Tavakkoli A, von Andrian U, Uldrich AP, Godfrey DI, Banks AS, Shay T, Brenner MB, Lynch L.
Nat Immunol
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Lysosome-Mediated Plasma Membrane Repair Is Dependent on the Small GTPase Arl8b and Determines Cell Death Type in Mycobacterium tuberculosis Infection.
Authors: Authors: Michelet X, Tuli A, Gan H, Geadas C, Sharma M, Remold HG, Brenner MB.
J Immunol
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Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.
Authors: Authors: Mizoguchi F, Slowikowski K, Wei K, Marshall JL, Rao DA, Chang SK, Nguyen HN, Noss EH, Turner JD, Earp BE, Blazar PE, Wright J, Simmons BP, Donlin LT, Kalliolias GD, Goodman SM, Bykerk VP, Ivashkiv LB, Lederer JA, Hacohen N, Nigrovic PA, Filer A, Buckley CD, Raychaudhuri S, Brenner MB.
Nat Commun
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Three classes of recurrent DNA break clusters in brain progenitors identified by 3D proximity-based break joining assay.
Authors: Authors: Wei PC, Lee CS, Du Z, Schwer B, Zhang Y, Kao J, Zurita J, Alt FW.
Proc Natl Acad Sci U S A
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DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions.
Authors: Authors: Panchakshari RA, Zhang X, Kumar V, Du Z, Wei PC, Kao J, Dong J, Alt FW.
Proc Natl Acad Sci U S A
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