The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.
Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation.
Polymorphic amplified typing sequences provide a novel approach to Escherichia coli O157:H7 strain typing.
Authors: Authors: Kudva IT, Evans PS, Perna NT, Barrett TJ, DeCastro GJ, Ausubel FM, Blattner FR, Calderwood SB.
J Clin Microbiol
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J Clin Microbiol
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Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms.
Authors: Authors: Kudva IT, Evans PS, Perna NT, Barrett TJ, Ausubel FM, Blattner FR, Calderwood SB.
J Bacteriol
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J Bacteriol
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MAP kinase signalling cascade in Arabidopsis innate immunity.
Authors: Authors: Asai T, Tena G, Plotnikova J, Willmann MR, Chiu WL, Gomez-Gomez L, Boller T, Ausubel FM, Sheen J.
Nature
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Nature
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Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis.
Authors: Authors: Choi JY, Sifri CD, Goumnerov BC, Rahme LG, Ausubel FM, Calderwood SB.
J Bacteriol
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J Bacteriol
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Caenorhabditis elegans as a host for the study of host-pathogen interactions.
Differential roles of the Pseudomonas aeruginosa PA14 rpoN gene in pathogenicity in plants, nematodes, insects, and mice.
Authors: Authors: Hendrickson EL, Plotnikova J, Mahajan-Miklos S, Rahme LG, Ausubel FM.
J Bacteriol
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J Bacteriol
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Isochorismate synthase is required to synthesize salicylic acid for plant defence.
A simple model host for identifying Gram-positive virulence factors.
Authors: Authors: Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, Calderwood SB, Ausubel FM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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The roles of mucD and alginate in the virulence of Pseudomonas aeruginosa in plants, nematodes and mice.
Authors: Authors: Yorgey P, Rahme LG, Tan MW, Ausubel FM.
Mol Microbiol
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Mol Microbiol
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