Frederick M. Ausubel, Ph.D

Professor of Genetics, Emeritus

617-726-5969

Research
Publications

The Ausubel laboratory uses genetic, genomic, and chemical genetic approaches to: (1) elucidate the molecular basis of microbial pathogenesis in the bacterial pathogens Pseudomonas aeruginosa and Pseudomonas syringae and (2) identify the components of the signaling pathways involved in the host innate immune response in the plant Arabidopsis thaliana and the nematode Caenorhabditis elegans.

An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections.

Authors: Authors: Koeva M, Gutu AD, Hebert W, Wager JD, Yonker LM, O'Toole GA, Ausubel FM, Moskowitz SM, Joseph-McCarthy D.
Antimicrob Agents Chemother 2017-12-01
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Investment in secreted enzymes during nutrient-limited growth is utility dependent.

Authors: Authors: Cezairliyan B, Ausubel FM.
Proc Natl Acad Sci U S A 2017-09-12
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Characterization of a Francisella tularensis-Caenorhabditis elegans Pathosystem for the Evaluation of Therapeutic Compounds.

Authors: Authors: Jayamani E, Tharmalingam N, Rajamuthiah R, Coleman JJ, Kim W, Okoli I, Hernandez AM, Lee K, Nau GJ, Ausubel FM, Mylonakis E.
Antimicrob Agents Chemother 2017-09-01
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The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events.

Authors: Authors: Urbach JM, Ausubel FM.
Proc Natl Acad Sci U S A 2017-01-31
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Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants.

Authors: Authors: Gregory KE, Samuel BS, Houghteling P, Shan G, Ausubel FM, Sadreyev RI, Walker WA.
Microbiome 2016-12-30
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Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway.

Authors: Authors: McEwan DL, Feinbaum RL, Stroustrup N, Haas W, Conery AL, Anselmo A, Sadreyev R, Ausubel FM.
BMC Biol 2016-12-07
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Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology.

Authors: Authors: Newman M, Ausubel FM.
Curr Protoc Mol Biol 2016-07-01
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Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome P450 83A1 Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance.

Authors: Authors: Liu S, Bartnikas LM, Volko SM, Ausubel FM, Tang D.
Front Plant Sci 2016-01-01
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NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption.

Authors: Authors: Kim W, Fricke N, Conery AL, Fuchs BB, Rajamuthiah R, Jayamani E, Vlahovska PM, Ausubel FM, Mylonakis E.
Future Med Chem 2016-01-01
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Pseudomonas syringae enhances herbivory by suppressing the reactive oxygen burst in Arabidopsis.

Authors: Authors: Groen SC, Humphrey PT, Chevasco D, Ausubel FM, Pierce NE, Whiteman NK.
J Insect Physiol 2016-01-01
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