Frederick W. Alt
Frederick W. Alt, PhD
Charles A. Janeway Professor of Pediatrics

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Synthesis of a novel alpha-galactosyl ceramide haptenated-lipid antigen, a useful tool in demonstrating the involvement of iNKT cells in the production of antilipid antibodies.
Authors: Authors: Veerapen N, Leadbetter EA, Brenner MB, Cox LR, Besra GS.
Bioconjug Chem
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Regulation of CD1 antigen-presenting complex stability.
Authors: Authors: Odyniec AN, Barral DC, Garg S, Tatituri RV, Besra GS, Brenner MB.
J Biol Chem
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How invariant natural killer T cells respond to infection by recognizing microbial or endogenous lipid antigens.
Authors: Authors: Brigl M, Brenner MB.
Semin Immunol
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Recognition of Cluster of Differentiation 1 Antigens by Human CD4-CD8- CytolyticT Lymphocyte. Nature. 1989. 341: 447-450. 1989.
Authors: Authors: Porcelli S, Brenner MB, Greenstein JL, Terhorst C, Balk SP, Bleicher PA.
J Immunol
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Activation state and intracellular trafficking contribute to the repertoire of endogenous glycosphingolipids presented by CD1d [corrected].
Authors: Authors: Muindi K, Cernadas M, Watts GF, Royle L, Neville DC, Dwek RA, Besra GS, Rudd PM, Butters TD, Brenner MB.
Proc Natl Acad Sci U S A
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Early recycling compartment trafficking of CD1a is essential for its intersection and presentation of lipid antigens.
Authors: Authors: Cernadas M, Cavallari M, Watts G, Mori L, De Libero G, Brenner MB.
J Immunol
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Synovial fibroblasts self-direct multicellular lining architecture and synthetic function in three-dimensional organ culture.
Authors: Authors: Kiener HP, Watts GF, Cui Y, Wright J, Thornhill TS, Sk├Âld M, Behar SM, Niederreiter B, Lu J, Cernadas M, Coyle AJ, Sims GP, Smolen J, Warman ML, Brenner MB, Lee DM.
Arthritis Rheum
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Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11.
Authors: Authors: Chang SK, Gu Z, Brenner MB.
Immunol Rev
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Rapid and reliable generation of invariant natural killer T-cell lines in vitro.
Authors: Authors: Chiba A, Cohen N, Brigl M, Brennan PJ, Besra GS, Brenner MB.
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CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.
Authors: Authors: Felio K, Nguyen H, Dascher CC, Choi HJ, Li S, Zimmer MI, Colmone A, Moody DB, Brenner MB, Wang CR.
J Exp Med
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