Frederick W. Alt

Frederick W. Alt, PhD

Charles A. Janeway Professor of Pediatrics

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells.

Authors: Authors: Kane H, LaMarche NM, Ní Scannail Á, Garza AE, Koay HF, Azad AI, Kunkenmoeller B, Stevens B, Brenner MB, Lynch L.
Elife 2022-12-02
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SLAMF7 engagement superactivates macrophages in acute and chronic inflammation.

Authors: Authors: Simmons DP, Nguyen HN, Gomez-Rivas E, Jeong Y, Jonsson AH, Chen AF, Lange JK, Dyer GS, Blazar P, Earp BE, Coblyn JS, Massarotti EM, Sparks JA, Todd DJ, Rao DA, Kim EY, Brenner MB.
Sci Immunol 2022-02-11
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Fibroblast pathology in inflammatory diseases.

Authors: Authors: Wei K, Nguyen HN, Brenner MB.
J Clin Invest 2021-10-15
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Distinct iNKT Cell Populations Use IFN? or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.

Authors: Authors: LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB.
Cell Metab 2020-08-04
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Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.

Authors: Authors: Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N.
Sci Adv 2020-06-01
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Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-? in NK cells.

Authors: Authors: Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB.
J Clin Invest 2020-06-01
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Notch signalling drives synovial fibroblast identity and arthritis pathology.

Authors: Authors: Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB.
Nature 2020-06-01
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Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.

Authors: Authors: Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL.
Proc Natl Acad Sci U S A 2020-04-21
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A Two-Cell Model for IL-1ß Release Mediated by Death-Receptor Signaling.

Authors: Authors: Donado CA, Cao AB, Simmons DP, Croker BA, Brennan PJ, Brenner MB.
Cell Rep 2020-04-07
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CUX1 and I?B? (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts.

Authors: Authors: Slowikowski K, Nguyen HN, Noss EH, Simmons DP, Mizoguchi F, Watts GFM, Gurish MF, Brenner MB, Raychaudhuri S.
Proc Natl Acad Sci U S A 2020-03-10
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