Frederick W. Alt
Frederick W. Alt, PhD
Charles A. Janeway Professor of Pediatrics

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11.
Authors: Authors: Chang SK, Gu Z, Brenner MB.
Immunol Rev
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CD1a and MHC class I follow a similar endocytic recycling pathway.
Authors: Authors: Barral DC, Cavallari M, McCormick PJ, Garg S, Magee AI, Bonifacino JS, De Libero G, Brenner MB.
Traffic
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Characterization of two avian MHC-like genes reveals an ancient origin of the CD1 family.
Authors: Authors: Miller MM, Wang C, Parisini E, Coletta RD, Goto RM, Lee SY, Barral DC, Townes M, Roura-Mir C, Ford HL, Brenner MB, Dascher CC.
Proc Natl Acad Sci U S A
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Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Authors: Authors: Cernadas M, Sugita M, van der Wel N, Cao X, Gumperz JE, Maltsev S, Besra GS, Behar SM, Peters PJ, Brenner MB.
J Immunol
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CD1-dependent dendritic cell instruction.
Authors: Authors: Vincent MS, Leslie DS, Gumperz JE, Xiong X, Grant EP, Brenner MB.
Nat Immunol
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The role of alpha and beta chains in ligand recognition by beta 7 integrins.
Authors: Authors: Higgins JM, Cernadas M, Tan K, Irie A, Wang J, Takada Y, Brenner MB.
J Biol Chem
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Expression of CD1d2 on thymocytes is not sufficient for the development of NK T cells in CD1d1-deficient mice.
Authors: Authors: Chen YH, Wang B, Chun T, Zhao L, Cardell S, Behar SM, Brenner MB, Wang CR.
J Immunol
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Assembly and retention of CD1b heavy chains in the endoplasmic reticulum.
Authors: Authors: Sugita M, Porcelli SA, Brenner MB.
J Immunol
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Direct presentation of nonpeptide prenyl pyrophosphate antigens to human gamma delta T cells.
Authors: Authors: Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DE, Brenner MB.
Immunity
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Murine M290 integrin expression modulated by mast cell activation.
Authors: Authors: Smith TJ, Ducharme LA, Shaw SK, Parker CM, Brenner MB, Kilshaw PJ, Weis JH.
Immunity
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