Frederick W. Alt
Frederick W. Alt, PhD
Charles A. Janeway Professor of Pediatrics
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Clonally expanded CD38hi cytotoxic CD8 T cells define the T cell infiltrate in checkpoint inhibitor-associated arthritis.
Authors: Authors: Wang R, Singaraju A, Marks KE, Shakib L, Dunlap G, Adejoorin I, Greisen SR, Chen L, Tirpack AK, Aude C, Fein MR, Todd DJ, MacFarlane L, Goodman SM, DiCarlo EF, Massarotti EM, Sparks JA, Jonsson AH, Brenner MB, Postow MA, Chan KK, Bass AR, Donlin LT, Rao DA.
Sci Immunol
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Adipocytes regulate fibroblast function, and their loss contributes to fibroblast dysfunction in inflammatory diseases.
Authors: Authors: Faust HJ, Cheng TY, Korsunsky I, Watts GFM, Gal-Oz ST, Trim W, Kongthong K, Jonsson AH, Simmons DP, Zhang F, Padera R, Chubinskaya S, Wei K, Raychaudhuri S, Lynch L, Moody DB, Brenner MB.
bioRxiv
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The Chromatin Landscape of Pathogenic Transcriptional Cell States in Rheumatoid Arthritis.
Authors: Authors: Weinand K, Sakaue S, Nathan A, Jonsson AH, Zhang F, Watts GFM, Zhu Z, Rao DA, Anolik JH, Brenner MB, Donlin LT, Wei K, Raychaudhuri S.
bioRxiv
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Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells.
Authors: Authors: Kane H, LaMarche NM, Ní Scannail Á, Garza AE, Koay HF, Azad AI, Kunkenmoeller B, Stevens B, Brenner MB, Lynch L.
Elife
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SLAMF7 engagement superactivates macrophages in acute and chronic inflammation.
Authors: Authors: Simmons DP, Nguyen HN, Gomez-Rivas E, Jeong Y, Jonsson AH, Chen AF, Lange JK, Dyer GS, Blazar P, Earp BE, Coblyn JS, Massarotti EM, Sparks JA, Todd DJ, Rao DA, Kim EY, Brenner MB.
Sci Immunol
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Fibroblast pathology in inflammatory diseases.
Authors: Authors: Wei K, Nguyen HN, Brenner MB.
J Clin Invest
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Distinct iNKT Cell Populations Use IFN? or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.
Authors: Authors: LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB.
Cell Metab
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Notch signalling drives synovial fibroblast identity and arthritis pathology.
Authors: Authors: Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB.
Nature
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Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.
Authors: Authors: Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N.
Sci Adv
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Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-? in NK cells.
Authors: Authors: Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB.
J Clin Invest
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