Frederick W. Alt
Frederick W. Alt, PhD
Charles A. Janeway Professor of Pediatrics

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

SLAMF7 engagement superactivates macrophages in acute and chronic inflammation.
Authors: Authors: Simmons DP, Nguyen HN, Gomez-Rivas E, Jeong Y, Jonsson AH, Chen AF, Lange JK, Dyer GS, Blazar P, Earp BE, Coblyn JS, Massarotti EM, Sparks JA, Todd DJ, Rao DA, Kim EY, Brenner MB.
Sci Immunol
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Fibroblast pathology in inflammatory diseases.
Authors: Authors: Wei K, Nguyen HN, Brenner MB.
J Clin Invest
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Distinct iNKT Cell Populations Use IFN? or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis.
Authors: Authors: LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB.
Cell Metab
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Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-? in NK cells.
Authors: Authors: Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB.
J Clin Invest
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Notch signalling drives synovial fibroblast identity and arthritis pathology.
Authors: Authors: Wei K, Korsunsky I, Marshall JL, Gao A, Watts GFM, Major T, Croft AP, Watts J, Blazar PE, Lange JK, Thornhill TS, Filer A, Raza K, Donlin LT, Siebel CW, Buckley CD, Raychaudhuri S, Brenner MB.
Nature
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Synoviocyte-targeted therapy synergizes with TNF inhibition in arthritis reversal.
Authors: Authors: Svensson MND, Zoccheddu M, Yang S, Nygaard G, Secchi C, Doody KM, Slowikowski K, Mizoguchi F, Humby F, Hands R, Santelli E, Sacchetti C, Wakabayashi K, Wu DJ, Barback C, Ai R, Wang W, Sims GP, Mydel P, Kasama T, Boyle DL, Galimi F, Vera D, Tremblay ML, Raychaudhuri S, Brenner MB, Firestein GS, Pitzalis C, Ekwall AH, Stanford SM, Bottini N.
Sci Adv
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Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Authors: Authors: Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL.
Proc Natl Acad Sci U S A
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A Two-Cell Model for IL-1ß Release Mediated by Death-Receptor Signaling.
Authors: Authors: Donado CA, Cao AB, Simmons DP, Croker BA, Brennan PJ, Brenner MB.
Cell Rep
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CUX1 and I?B? (NFKBIZ) mediate the synergistic inflammatory response to TNF and IL-17A in stromal fibroblasts.
Authors: Authors: Slowikowski K, Nguyen HN, Noss EH, Simmons DP, Mizoguchi F, Watts GFM, Gurish MF, Brenner MB, Raychaudhuri S.
Proc Natl Acad Sci U S A
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Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci.
Authors: Authors: Gutierrez-Arcelus M, Baglaenko Y, Arora J, Hannes S, Luo Y, Amariuta T, Teslovich N, Rao DA, Ermann J, Jonsson AH, Navarrete C, Rich SS, Taylor KD, Rotter JI, Gregersen PK, Esko T, Brenner MB, Raychaudhuri S.
Nat Genet
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