Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital
Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital
Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School
617-919-2539
Frederick Alt Website

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Mechanisms of Vdelta1 gammadelta T cell activation by microbial components.
Authors: Authors: Das H, Sugita M, Brenner MB.
J Immunol
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New insights into pathways for CD1-mediated antigen presentation.
Authors: Authors: Sugita M, Cernadas M, Brenner MB.
Curr Opin Immunol
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T cell activation by lipopeptide antigens.
Authors: Authors: Moody DB, Young DC, Cheng TY, Rosat JP, Roura-Mir C, O'Connor PB, Zajonc DM, Walz A, Miller MJ, Levery SB, Wilson IA, Costello CE, Brenner MB.
Science
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Critical role of T cell-dependent serum antibody, but not the gut-associated lymphoid tissue, for surviving acute mucosal infection with Citrobacter rodentium, an attaching and effacing pathogen.
Authors: Authors: Bry L, Brenner MB.
J Immunol
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CD1: antigen presentation and T cell function.
Authors: Authors: Brigl M, Brenner MB.
Annu Rev Immunol
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Mechanism of CD1d-restricted natural killer T cell activation during microbial infection.
Authors: Authors: Brigl M, Bry L, Kent SC, Gumperz JE, Brenner MB.
Nat Immunol
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Restoration of first-phase insulin secretion by the imidazoline compound LY374284 in pancreatic islets of diabetic db/db mice.
Authors: Authors: Brenner MB, Gromada J, Efanov AM, Bokvist K, Mest HJ.
Ann N Y Acad Sci
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Structural features of the acyl chain determine self-phospholipid antigen recognition by a CD1d-restricted invariant NKT (iNKT) cell.
Authors: Authors: Rauch J, Gumperz J, Robinson C, Sköld M, Roy C, Young DC, Lafleur M, Moody DB, Brenner MB, Costello CE, Behar SM.
J Biol Chem
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Flexible migration program regulates gamma delta T-cell involvement in humoral immunity.
Authors: Authors: Brandes M, Willimann K, Lang AB, Nam KH, Jin C, Brenner MB, Morita CT, Moser B.
Blood
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Lysosomal localization of murine CD1d mediated by AP-3 is necessary for NK T cell development.
Authors: Authors: Cernadas M, Sugita M, van der Wel N, Cao X, Gumperz JE, Maltsev S, Besra GS, Behar SM, Peters PJ, Brenner MB.
J Immunol
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