Frederick W. Alt

Frederick W. Alt, Ph.D.

Director, Program in Cellular and Molecular Medicine at Boston Children's Hospital

Principal Investigator, Howard Hughes Medical Institute at Boston Children's Hospital

Charles A. Janeway Professor of Pediatrics and Genetics, Harvard Medical School

617-919-2539

Research
Publications

The Alt laboratory studies mechanisms that maintain genomic stability in mammalian cells. The programmed recombination and hypermutation events in lymphocytes and the general DNA repair mechanisms involved in these processes are a focus. The laboratory also studies mechanisms that promote and prevent oncogenic translocations. Approaches range from molecular genetics and biochemistry to animal models.

Identification of shared antigenic determinants of the putative human T lymphocyte antigen receptor.

Authors: Authors: Brenner MB, Trowbridge IS, McLean J, Strominger JL.
J Exp Med 1984-08-01
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Antigenic stimulation regulates the level of expression of interleukin 2 receptor on human T cells.

Authors: Authors: Hemler ME, Brenner MB, McLean JM, Strominger JL.
Proc Natl Acad Sci U S A 1984-04-01
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In vitro T lymphocyte proliferative response to Yersinia enterocolitica in Reiter's syndrome. Lack of response in other HLA-B27 positive individuals.

Authors: Authors: Brenner MB, Kobayashi S, Wiesenhutter CW, Huberman AK, Bales P, Yu DT.
Arthritis Rheum 1984-03-01
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Med (N Y)

Authors: Authors: Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases
2022 07 08; 3(7):481-518.e14.
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Sci Transl Med

Authors: Authors: Granzyme K+ CD8 T cells form a core population in inflamed human tissue
2022 06 15; 14(649):eabo0686.
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