Gary B. Ruvkun

Gary B. Ruvkun, Ph.D.

Professor of Genetics, Harvard Medical School

Department of Molecular Biology, Massachusetts General Hospital

617-726-5959

Ruvkun Lab Website

Publications

Translation elongation defects activate the Caenorhabditis elegans ZIP-2 bZIP transcription factor-mediated toxin defense.

Authors: Authors: Kniazeva M, Ruvkun G.
Proc Natl Acad Sci U S A 2025-02-11
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Hydrogen sulfide mediates the interaction between C. elegans and Actinobacteria from its natural microbial environment.

Authors: Authors: Patange O, Breen P, Arsuffi G, Ruvkun G.
Cell Rep 2025-01-08
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Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans.

Authors: Authors: Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G.
PLoS Biol 2025-01-01
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Caenorhabditis elegans inositol hexaphosphate pathways couple to RNA interference and pathogen defense.

Authors: Authors: Xu W, Sun Y, Breen P, Ruvkun G, Mao K.
Proc Natl Acad Sci U S A 2024-12-03
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Caenorhabditis elegans SynMuv B gene activity is down-regulated during a viral infection to enhance RNA interference.

Authors: Authors: Seetharaman A, Galagali H, Linarte E, Liu MHX, Cohen JD, Chetal K, Sadreyev R, Tate AJ, Montgomery TA, Ruvkun G.
bioRxiv 2024-07-16
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Mutations in nucleotide metabolism genes bypass proteasome defects in png-1/NGLY1-deficient Caenorhabditis elegans.

Authors:
PLoS Biol 2024-07-11
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CMTR-1 RNA methyltransferase mutations activate widespread expression of a dopaminergic neuron-specific mitochondrial complex I gene.

Authors: Authors: Meisel JD, Wiesenthal PP, Mootha VK, Ruvkun G.
Curr Biol 2024-05-24
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Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans.

Authors: Authors: Warnhoff K, Bhattacharya S, Snoozy J, Breen PC, Ruvkun G.
Elife 2024-02-13
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Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism.

Authors: Authors: Meisel JD, Miranda M, Skinner OS, Wiesenthal PP, Wellner SM, Jourdain AA, Ruvkun G, Mootha VK.
Cell 2024-02-01
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Hypoxia-inducible factor induces cysteine dioxygenase and promotes cysteine homeostasis in Caenorhabditis elegans.

Authors: Authors: Warnhoff K, Bhattacharya S, Snoozy J, Breen PC, Ruvkun G.
bioRxiv 2023-11-01
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