Gary B. Ruvkun, Ph.D.
Professor of Genetics, Harvard Medical School
Department of Molecular Biology, Massachusetts General Hospital
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons.
Authors: Authors: Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L.
Nature
View full abstract on Pubmed
Nature
View full abstract on Pubmed
Negative regulatory sequences in the lin-14 3'-untranslated region are necessary to generate a temporal switch during Caenorhabditis elegans development.
Authors: Authors: Wightman B, Bürglin TR, Gatto J, Arasu P, Ruvkun G.
Genes Dev
View full abstract on Pubmed
Genes Dev
View full abstract on Pubmed
Temporal regulation of lin-14 by the antagonistic action of two other heterochronic genes, lin-4 and lin-28.
Nematode homeobox cluster.
Authors: Authors: Bürglin TR, Ruvkun G, Coulson A, Hawkins NC, McGhee JD, Schaller D, Wittmann C, Müller F, Waterston RH.
Nature
View full abstract on Pubmed
Nature
View full abstract on Pubmed
Regulation of transcription and cell identity by POU domain proteins.
Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes.
The unc-86 gene product couples cell lineage and cell identity in C. elegans.
Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.
Caenorhabditis elegans has scores of homoeobox-containing genes.
The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch.