Gary B. Ruvkun, Ph.D.
Professor of Genetics, Harvard Medical School
Department of Molecular Biology, Massachusetts General Hospital
Dominant gain-of-function mutations that lead to misregulation of the C. elegans heterochronic gene lin-14, and the evolutionary implications of dominant mutations in pattern-formation genes.
The unc-86 gene product couples cell lineage and cell identity in C. elegans.
Detection of mutations and DNA polymorphisms using whole genome Southern Cross hybridization.
Caenorhabditis elegans has scores of homoeobox-containing genes.
The Caenorhabditis elegans heterochronic gene lin-14 encodes a nuclear protein that forms a temporal developmental switch.
Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14.
Authors: Authors: Ruvkun G, Ambros V, Coulson A, Waterston R, Sulston J, Horvitz HR.
Genetics
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Genetics
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The C. elegans cell lineage and differentiation gene unc-86 encodes a protein with a homeodomain and extended similarity to transcription factors.
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.
Authors: Authors: Herr W, Sturm RA, Clerc RG, Corcoran LM, Baltimore D, Sharp PA, Ingraham HA, Rosenfeld MG, Finney M, Ruvkun G, et al.
Genes Dev
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Genes Dev
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Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts.
Directed transposon Tn5 mutagenesis and complementation analysis of Rhizobium meliloti symbiotic nitrogen fixation genes.