Medical digital twins: enabling precision medicine and medical artificial intelligence.
Authors: Authors: Sadée C, Testa S, Barba T, Hartmann K, Schuessler M, Thieme A, Church GM, Okoye I, Hernandez-Boussard T, Hood L, Shmulevich I, Kuhl E, Gevaert O.
Lancet Digit Health
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Lancet Digit Health
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Machine-guided cell-fate engineering.
Authors: Authors: Appleton E, Tao J, Liu S, Glass C, Fonseca G, Church G.
Cell Rep
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Cell Rep
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Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC.
Authors: Authors: Liu S, Li L, Zhang F, Garcia-Corral M, Meyer K, Fortuna PRJ, van Sambeek B, Appleton E, Ng AHM, Khoshakhlagh P, Lu YR, Cameron J, Ramirez RN, Chen Y, Wu CT, Huang JY, Tan Y, Chao G, Aach J, Lim ET, Tam JM, Raychaudhuri S, Church GM.
Nat Commun
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Nat Commun
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A call for built-in biosecurity safeguards for generative AI tools.
Authors: Authors: Wang M, Zhang Z, Bedi AS, Velasquez A, Guerra S, Lin-Gibson S, Cong L, Qu Y, Chakraborty S, Blewett M, Ma J, Xing E, Church G.
Nat Biotechnol
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Nat Biotechnol
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DNA-PAINT Imaging with Hydrogel Imprinting and Clearing.
Template-independent enzymatic synthesis of RNA oligonucleotides.
Authors: Authors: Wiegand DJ, Rittichier J, Meyer E, Lee H, Conway NJ, Ahlstedt D, Yurtsever Z, Rainone D, Kuru E, Church GM.
Nat Biotechnol
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Nat Biotechnol
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A diverse single-stranded DNA-annealing protein library enables efficient genome editing across bacterial phyla.
Authors: Authors: Filsinger GT, Mychack A, Lyerly E, Henriksen C, Bartlett TM, Kuchwara H, Eitzinger S, Bernhardt TG, Walker S, Church GM, Wannier TM.
Proc Natl Acad Sci U S A
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Proc Natl Acad Sci U S A
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High-Throughput Extracellular Vesicle Isolation Using Plate-Based Size Exclusion Chromatography and Automation.
Authors: Authors: Gilboa T, Ter-Ovanesyan D, Babila CM, Whiteman S, Morton S, Kalish D, Johnston J, Tesin D, Davies M, Tam JM, Church GM, Walt DR.
J Am Chem Soc
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J Am Chem Soc
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Engineering gene drive docking sites in a haplolethal locus in Anopheles gambiae.
Authors: Authors: Smidler AL, Marrogi EA, Scott S, Mameli E, Abernathy D, Akbari OS, Church GM, Catteruccia F, Esvelt K.
bioRxiv
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bioRxiv
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Circular Vectors as an efficient, fully synthetic, cell-free approach for preparing small circular DNA as a plasmid substitute for guide RNA expression in CRISPR-Cas9 genome editing.