Jeannie T. Lee, M.D., Ph.D.
Phillip A. Sharp Chair in Molecular Biology, Massachusetts General Hospital
Vice Chair of the Department of Genetics, Harvard Medical School
Professor of Genetics and Pathology, Harvard Medical School
Re-analysis of CLAP data affirms PRC2 as an RNA binding protein.
PRC2-RNA interactions: Viewpoint from YongWoo Lee and Jeannie T. Lee.
Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression.
G-quadruplex folding in Xist RNA antagonizes PRC2 activity for stepwise regulation of X chromosome inactivation.
Imprinted X chromosome inactivation at the gamete-to-embryo transition.
Variable expression of MECP2, CDKL5, and FMR1 in the human brain: Implications for gene restorative therapies.
Site-specific R-loops induce CGG repeat contraction and fragile X gene reactivation.
Authors: Authors: Lee HG, Imaichi S, Kraeutler E, Aguilar R, Lee YW, Sheridan SD, Lee JT.
Cell
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Cell
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Targeting RNA with small molecules: lessons learned from Xist RNA.
Targeting Xist with compounds that disrupt RNA structure and X inactivation.
Authors: Authors: Aguilar R, Spencer KB, Kesner B, Rizvi NF, Badmalia MD, Mrozowich T, Mortison JD, Rivera C, Smith GF, Burchard J, Dandliker PJ, Patel TR, Nickbarg EB, Lee JT.
Nature
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Nature
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Selective Xi reactivation and alternative methods to restore MECP2 function in Rett syndrome.