Jeannie Lee headshot

Jeannie T. Lee, M.D., Ph.D.

Phillip A. Sharp Chair in Molecular Biology, Massachusetts General Hospital
Vice Chair of the Department of Genetics, Harvard Medical School
Professor of Genetics and Pathology, Harvard Medical School
617-726-5943
Lee Lab Website
Role of the Chromosome Architectural Factor SMCHD1 in X-Chromosome Inactivation, Gene Regulation, and Disease in Humans.
Authors: Authors: Wang CY, Brand H, Shaw ND, Talkowski ME, Lee JT.
Genetics
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PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments.
Authors: Authors: Wang CY, Colognori D, Sunwoo H, Wang D, Lee JT.
Nat Commun
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Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X.
Authors: Authors: Colognori D, Sunwoo H, Kriz AJ, Wang CY, Lee JT.
Mol Cell
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Exploration of CTCF post-translation modifications uncovers Serine-224 phosphorylation by PLK1 at pericentric regions during the G2/M transition.
Authors: Authors: Del Rosario BC, Kriz AJ, Del Rosario AM, Anselmo A, Fry CJ, White FM, Sadreyev RI, Lee JT.
Elife
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Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape.
Authors: Authors: Froberg JE, Pinter SF, Kriz AJ, Jégu T, Lee JT.
Nat Commun
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Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans.
Authors: Authors: Saltzman AL, Soo MW, Aram R, Lee JT.
Genetics
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Loss of H3K27me3 Imprinting in Somatic Cell Nuclear Transfer Embryos Disrupts Post-Implantation Development.
Authors: Authors: Matoba S, Wang H, Jiang L, Lu F, Iwabuchi KA, Wu X, Inoue K, Yang L, Press W, Lee JT, Ogura A, Shen L, Zhang Y.
Cell Stem Cell
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Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function.
Authors: Authors: Carrette LLG, Blum R, Ma W, Kelleher RJ, Lee JT.
Proc Natl Acad Sci U S A
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SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X.
Authors: Authors: Wang CY, Jégu T, Chu HP, Oh HJ, Lee JT.
Cell
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A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders.
Authors: Authors: Carrette LLG, Wang CY, Wei C, Press W, Ma W, Kelleher RJ, Lee JT.
Proc Natl Acad Sci U S A
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