Jeannie T. Lee, M.D., Ph.D.
Phillip A. Sharp Chair in Molecular Biology, Massachusetts General Hospital
Vice Chair of the Department of Genetics, Harvard Medical School
Professor of Genetics and Pathology, Harvard Medical School
The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation.
The X as model for RNA's niche in epigenomic regulation.
Retinoic acid accelerates downregulation of the Xist repressor, Oct4, and increases the likelihood of Xist activation when Tsix is deficient.
Two-step imprinted X inactivation: repeat versus genic silencing in the mouse.
Authors: Authors: Namekawa SH, Payer B, Huynh KD, Jaenisch R, Lee JT.
Mol Cell Biol
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Mol Cell Biol
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Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations.
Authors: Authors: Lengner CJ, Gimelbrant AA, Erwin JA, Cheng AW, Guenther MG, Welstead GG, Alagappan R, Frampton GM, Xu P, Muffat J, Santagata S, Powers D, Barrett CB, Young RA, Lee JT, Jaenisch R, Mitalipova M.
Cell
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Cell
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Extending the frontiers of epigenetic regulation.
Characterization of X-chromosome inactivation status in human pluripotent stem cells.
Characterization of Xpr (Xpct) reveals instability but no effects on X-chromosome pairing or Xist expression.
Authors: Authors: Sun S, Fukue Y, Nolen L, Sadreyev R, Lee JT.
Transcription
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Transcription
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Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene.
Authors: Authors: Zhou D, Conrad C, Xia F, Park JS, Payer B, Yin Y, Lauwers GY, Thasler W, Lee JT, Avruch J, Bardeesy N.
Cancer Cell
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Cancer Cell
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Lessons from X-chromosome inactivation: long ncRNA as guides and tethers to the epigenome.